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HF-rTMS of the left DLPFC relieve headaches and enhance frontal-temporal connectivity in migraine

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机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [2]Beijing Key Laboratory of Neuromodulation, Beijing 100053, China [3]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100053, China [4]Center for Sleep and Consciousness Disorders, Beijing Institute for Brain Disorders, Beijing 100053, China [5]Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100053, China [6]School of Life Science and Technology, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China

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关键词： Migraine DLPFC HF-rTMS TMS-EEG Brain network

摘要：

Migraine is a neurological disorder linked to altered cortical excitability. High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) is a promising non-invasive method for modulating nociceptive circuits, yet its precise mechanisms remain unclear. This study applied HF-rTMS to the left dorsolateral prefrontal cortex (DLPFC) and assessed brain network changes using transcranial magnetic stimulation combined with electroencephalography (TMS-EEG).We analyzed dynamic brain connectivity in 15 migraine patients versus 15 healthy controls. A randomized, double-blind, sham-controlled trial evaluated a 14-day HF-rTMS (20 Hz) protocol in 28 migraine patients. Brain network reorganization and migraine severity, measured by the Visual Analog Scale (VAS) and monthly migraine days (MMD), were assessed both immediately after treatment and at a one-month follow-up.Migraine patients exhibited reduced left DLPFC connectivity compared to healthy controls. HF-rTMS significantly increased frontal-temporal network connectivity, correlating with a marked reduction in VAS and MMD scores (p < 0.001).These findings provide novel evidence that HF-rTMS targeting the left DLPFC effectively alleviates migraine symptoms by enhancing frontal-temporal cortical plasticity.This study highlights the potential of neuromodulation techniques in the treatment of migraine.Copyright © 2025 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [2]Beijing Key Laboratory of Neuromodulation, Beijing 100053, China [3]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100053, China [4]Center for Sleep and Consciousness Disorders, Beijing Institute for Brain Disorders, Beijing 100053, China [5]Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100053, China

通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [2]Beijing Key Laboratory of Neuromodulation, Beijing 100053, China [3]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100053, China [4]Center for Sleep and Consciousness Disorders, Beijing Institute for Brain Disorders, Beijing 100053, China [5]Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100053, China

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HF-rTMS of the left DLPFC relieve headaches and enhance frontal-temporal connectivity in migraine

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