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Cavernous sinus syndrome in a patient with occult nasopharyngeal carcinoma: A diagnostic challenge

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机构： [1]Department of Oncology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Siliu South Road No.127, Qingdao 266042, China. [2]Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. [3]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.

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关键词： Cavernous sinus syndrome Nasopharyngeal carcinoma Early diagnosis Quality of life

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Nasopharyngeal carcinoma(NPC) is an epithelial malignancy of the nasopharyngeal mucosa. It typically exhibits local infiltration with frequent skull base involvement and often presents with multiple cranial neuropathies. It can invade the cavernous sinus via the skull base and foramen ovals, thereby causing cavernous sinus syndrome (CSS). When NPC invades nerves, the mass in the nasopharyngeal cavity may not be obvious. We report a case of CSS presenting as painful ophthalmoplegia or nonspecific inflammation. While initial glucocorticoid therapy provided transient symptom relief, the patient developed progressive neurological deficits. Ultimately, nasopharyngoscopic biopsy confirmed NPC through histopathological verification.Copyright © 2025. Published by Elsevier Ltd.

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出版当年[2025]版：

大类 | 2 区医学

小类 | 2 区牙科与口腔外科 3 区肿瘤学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区牙科与口腔外科 3 区肿瘤学

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第一作者机构： [1]Department of Oncology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Siliu South Road No.127, Qingdao 266042, China.

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