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Voclosporin promotes neurological function recovery by inhibiting inflammation and maintaining blood-brain barrier integrity following rtPA reperfusion after MCAO in mice

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机构： [1]Department of Neurology, Central Hospital of Dalian University of Technology, Dalian 116000, China [2]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [3]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China [4]Department of Neurology, Dalian No. 3 People’s Hospital, Dalian, China

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关键词： Voclosporin rtPA Blood–brain barrier Ischemic stroke

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Hemorrhagic transformation (HT) is the most serious complication after rtPA thrombolytic therapy in patients with acute ischemic stroke, which greatly limits the clinical application of rtPA. rtPA disruption of the blood-brain barrier (BBB) by inducing inflammation after cerebral ischemia may be an important mechanism for the development of HT, and maintaining BBB integrity can significantly reduce the risk of HT. Our study found that a new generation of calcineurin inhibitors, voclosporin can improve neurological function, reduce neuronal damage, and reduce cerebral infarction volume in mice. By Evans blue extravasation assay and cerebral water content measurement, it was found that voclosporin could improve BBB injury and reduce brain edema caused by rt-PA. The ELISA and immunofluorescence experiments further proved that voclosporin can reduce the expression of IL-1β/TNF-α, increase the expression of IL-10/IL-4, and protect the integrity of the BBB by promoting microglia/macrophage to M2 type polarization, providing new thinking for clinical rtPA combined therapy to alleviate BBB damage.© 2025. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 2 区毒理学 3 区免疫学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区毒理学 3 区免疫学

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出版当年[2023]版：

Q1 TOXICOLOGY Q2 IMMUNOLOGY

最新[2024]版：

Q1 IMMUNOLOGY Q1 TOXICOLOGY

影响因子： 5.3 最新[2024版] 5.2 最新五年平均 4.6 出版当年[2023版] 4.5 出版当年五年平均 5.8 出版前一年[2022版] 5.3 出版后一年[2024版]

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第一作者机构： [2]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [3]Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China

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