Deep brain stimulation of anterior nucleus of the thalamus (ANT-DBS) is an effective clinical treatment for drugresistant focal epilepsy. However, the complex epileptic network characteristics underlying ANT-stimulation effectiveness remain unknown, owing to currently unclear connectivity between ANT and seizure-related cortex in pre-ictal periods. Here, we developed a novel individualized pre-ictal ANT-cortical tripartite connectivity network (PANT-CTCNet), aiming to reveal epileptic network characteristics using intracranial stereoelectroencephalography (sEEG) recordings in five patients with focal epilepsy for 90 trials. Each trial represented a pre-ictal or post-stimulus sEEG duration, which was used to construct the epileptic network. By employing conditional Granger causality, we constructed individualized ANT-cortical connectivity networks and found a common epileptic network centred on ANT closely connected with seizure-related cortex in pre-ictal periods. After ANT stimulation for clinical validation, strengthened pre-ictal connectivity between ANT and epileptogenic zones led to significant decline in the causal intensity of epileptic networks. The PANT-CTCNet can give a quantitative reference for clinical preoperative evaluation of patient suitability for ANT-DBS treatment. These findings regarding epileptic network characteristics provide theoretical basis in the selection of optimal surgical candidates for personalized ANT-DBS.