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Potential Protective Effects of Chronic Anterior Thalamic Nucleus Stimulation on Hippocampal Neurons in Epileptic Monkeys.

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收录情况： ◇ SCIE

作者：
Yang An-Chao[1] * ; Shi Lin[1,2] * ; Li Lu-Ming[3,6] ; Li Jun-Ju[1,4] ; Jiang Yin[2] ; Meng Da-Wei[1] ; Zhu Guan-Yu[1] ; Chen Ying-Chuan[1] ; Lu De-Hong[5] ; Zhang Jian-Guo[1,2,6,*1] ;
机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China [2]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China [3]Department of Aeronautics and Astronautics, Tsinghua University, Beijing 100084, China [4]Department of Neurosurgery, People’s Hospital of Hainan Province, Haikou 570100, China [5]Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing 100000, China [6]Beijing Key Laboratory of Neurostimulation, Beijing 100050, China
出处：
DOI： 10.1016/j.brs.2015.07.041
ISSN：

关键词： Anterior nucleus of the thalamus Deep brain stimulation Epilepsy Neuronal injury Rhesus monkey

摘要：
Stimulation of the anterior nucleus of the thalamus (ANT) is effective in seizure reduction, but the mechanisms underlying the beneficial effects of ANT stimulation are unclear.To assess the beneficial effects of ANT stimulation on hippocampal neurons of epileptic monkeys.Chronic ANT stimulation was applied to kainic acid-induced epileptic monkeys. Behavioral seizures were continuously monitored. Immunohistochemical staining and western blot assays were performed to assess the hippocampal injury and the effects of ANT stimulation.The frequency of seizures was 42.8% lower in the stimulation group compared with the sham-stimulation group. Immunohistochemical staining and western blot analyses indicated that neuronal loss and apoptosis were less severe and that neurofilament synthesis was enhanced in the stimulation monkeys compared with the sham-stimulation group. These data showed that the hippocampal injury was less severe in monkeys in the stimulation group than in those in the sham-stimulation group.Our data suggest that chronic ANT stimulation may exert protective effects on hippocampal neurons and boost the regeneration of neuronal fibers. These effects may be closely related to the mechanisms of ANT stimulation in epilepsy treatment.Copyright © 2015 Elsevier Inc. All rights reserved.

基金：
National Natural Science Funds for Distinguished Young Scholars (Grant No. 81200997), by the Beijing Municipal Science and Technology Commission (Grant No. Z121107001012062) and by the Beijing Municipal Administration of Hospitals Clinical Medicine Department of Special Funding (Grant No. ZYLX201305)
语种：
外文
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中科院(CAS)分区：
出版当年[2014]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 神经科学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学 1 区 神经科学
JCR分区：
出版当年[2013]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES
最新[2023]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者：
第一作者机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China [2]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China [6]Beijing Key Laboratory of Neurostimulation, Beijing 100050, China [*1]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Tiantan West No.6, Dongcheng District, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Yang An-Chao,Shi Lin,Li Lu-Ming,et al.Potential Protective Effects of Chronic Anterior Thalamic Nucleus Stimulation on Hippocampal Neurons in Epileptic Monkeys.[J].BRAIN STIMULATION.2015,8(6):1049-1057.doi:10.1016/j.brs.2015.07.041.
APA：
Yang An-Chao,Shi Lin,Li Lu-Ming,Li Jun-Ju,Jiang Yin...&Zhang Jian-Guo.(2015).Potential Protective Effects of Chronic Anterior Thalamic Nucleus Stimulation on Hippocampal Neurons in Epileptic Monkeys..BRAIN STIMULATION,8,(6)
MLA：
Yang An-Chao,et al."Potential Protective Effects of Chronic Anterior Thalamic Nucleus Stimulation on Hippocampal Neurons in Epileptic Monkeys.".BRAIN STIMULATION 8..6(2015):1049-1057

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