机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[2]Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Beijing, China研究所北京市神经外科研究所首都医科大学附属天坛医院[3]Department of Neurosurgery, People’s Hospital of Hainan Province, Haikou, China
BackgroundPatients with implanted deep brain stimulation (DBS) hardware are prohibited from undergoing magnetic resonance imaging (MRI) scans at magnitudes greater than 1.5 T to avoid potential MRI-related heating injury. Whether DBS devices are compatible with higher field MRI scanning is unknown. This study aimed to investigate whether 7.0 T and 3.0 T MRI scans can be safely performed on rhesus monkeys with implanted DBS devices. MethodsEight male rhesus monkeys were included in this study and stereotactically implanted with DBS devices in the left anterior thalamus. Two weeks after DBS device implantation, 7.0 T and 3.0 T MRI scans were performed. The monkeys were observed for 72 hours. After explantation of the DBS system, 7.0 T MRI was repeated to determine potential lesions. Hematoxylin and eosin staining and transmission electron microscopy were conducted to assess pathological alterations. ResultsIn both groups, the monkeys exhibited no behavioral changes related to neurological deficits. Post-explantation MRI showed no malacia foci surrounding the DBS tracks. Additionally, neither hematoxylin and eosin staining nor transmission electron microscopy showed clear injury near the DBS leads. ConclusionThese results indicate that no obvious heating injury was induced in the tissue surrounding the DBS leads by the 7.0 T and 3.0 T MRI scans. Although the results of this study may not be generalizable, these data suggest that patients with implanted DBS devices can undergo even 7.0 T MRI without risk of brain injury.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81641052]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区临床神经病学3 区医学：研究与实验
最新[2025]版：
大类|3 区医学
小类|3 区临床神经病学3 区医学：研究与实验
JCR分区：
出版当年[2016]版：
Q2CLINICAL NEUROLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q2CLINICAL NEUROLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Beijing, China[3]Department of Neurosurgery, People’s Hospital of Hainan Province, Haikou, China
通讯作者：
通讯机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Beijing, China[*1]Beijing Neurosurgical Institute, Tiantan West No. 6, Dongcheng District, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Jun-Ju Li,Lin Shi,Ying-Chuan Chen,et al.Ultrahigh-Magnitude Brain Magnetic Resonance Imaging Scan on Rhesus Monkeys With Implanted Deep Brain Stimulation Hardware[J].NEUROMODULATION.2018,21(2):168-175.doi:10.1111/ner.12735.
APA：
Jun-Ju Li,Lin Shi,Ying-Chuan Chen,Guan-Yu Zhu&Jian-Guo Zhang.(2018).Ultrahigh-Magnitude Brain Magnetic Resonance Imaging Scan on Rhesus Monkeys With Implanted Deep Brain Stimulation Hardware.NEUROMODULATION,21,(2)
MLA：
Jun-Ju Li,et al."Ultrahigh-Magnitude Brain Magnetic Resonance Imaging Scan on Rhesus Monkeys With Implanted Deep Brain Stimulation Hardware".NEUROMODULATION 21..2(2018):168-175
