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IgG4-related lung disease with pulmonary lesions and recurrent pleural effusion: A case of report

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机构： [1]Department of Respiratory Disease, Xuanwu Hospital, Capital Medical University, Beijing, PR China. [2]Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.

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We report a rare case of IgG4-related lung disease (RLD) with pulmonary lesions and recurrent pleural effusion to improve the diagnosis and treatment of this disease. A 60-year-old man was admitted to hospital for cough and dyspnea. CT scan showed a right lower lobe intrapulmonary mass with unilateral right-sided pleural effusion. Histology revealed no malignant findings. After 1 year, the patient re-admitted to our hospital with high serum level of IgG4 and IgE concentrations. CT scan demonstrated partial resolution of intrapulmonary mass and right-sided pleural effusion, while concurrently revealing interval development of substantial left-sided pleural effusion. The patient was diagnosed with IgG4-RLD by biopsy finally. This is a first case report of IgG4-RLD with intrapulmonary lesions accompanied by asynchronous, rapidly accumulating bilateral pleural effusions. Clinicians should consider the possibility of IgG4-RLD with intrapulmonary lesions accompanied by asynchronous, rapidly growing bilateral pleural effusion, particularly after rigorously excluding common diseases.© 2025 The Authors. Published by Elsevier Inc. on behalf of University of Washington.

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第一作者机构： [1]Department of Respiratory Disease, Xuanwu Hospital, Capital Medical University, Beijing, PR China.

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