Rs548234 polymorphism at PRDM1-ATG5 region susceptible to rheumatoid arthritis in Caucasians is not associated with rheumatoid arthritis in Chinese Han population
机构:[1]Department of Rheumatology and Immunology, Peking UniversityPeople's Hospital, Beijing 100044, China[2]Renal Division, Peking University First Hospital, PekingUniversity Institute of Nephrology, Key Laboratory of RenalDisease, Ministryof Health of China, Beijing 10O034, China[3]Department of Rheumatology,Xuanwu Hospital, Capital MedicalUniversity, Beijing 100053, China首都医科大学宣武医院[4]Department of Rheumatology, Guang anmen Hospital,China Academy of Chinese Medical Sciences, Beijing 100053, China[5]Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China[6]Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, Sichuan 61004l, China[7]Department of Rheumatology, Drum Tower Hospital,Nanjing University Medical School, Nanjing, Jiangsu 210008, China
Background A previous study has shown that rs548234 polymorphism at PRDM1-ATG5 region is associated with rheumatoid arthritis (RA) in Caucasian populations. The aim of this study was to investigate the effect of rs548234 polymorphism at PRDM1-ATG5 region on susceptibility to RA in Chinese Han population. Methods We genotyped 848 RA patients and 1431 matched healthy controls for rs548234 single-nucleotide polymorphism (SNP) with a predesigned TaqMan SNP genotyping assay. Association analyses were performed on the whole data set and on rheumatoid factors (RF) and anti-cyclic citrullinated peptides (anti-CCP) antibody. Finally, we carried out combined analysis of rs548234 association with RA based on the published data. Results No significant difference in the genotype distribution between RA patients and healthy controls for rs548234 (UT) polymorphism was found in Chinese Han population, neither in whole data set nor in stratified subsets, e.g. RF and anti-CCP status. Association analysis in different ethnic groups showed that rs548234 at PRDM1-ATG5 region was associated with RA in Caucasian ancestry but not in East Asian population. Conclusions Our results showed no involvement of rs548234 at PRDM1-ATG5 region in the susceptibility or clinical relevance of RA in Chinese Han population. Chin Med J 2011;124(18):2863-2867
基金:
the Major State BasicResearch Development Program of China (973 Program) (No.20 1(CB529100) and Key Program of the National Natural ScienceFoundation of China (No.81030057).
第一作者机构:[1]Department of Rheumatology and Immunology, Peking UniversityPeople's Hospital, Beijing 100044, China
通讯作者:
通讯机构:[1]Department of Rheumatology and Immunology, Peking UniversityPeople's Hospital, Beijing 100044, China
推荐引用方式(GB/T 7714):
LU Xiao-lan,ZHOU Xu-jie,GUO Jian-ping,et al.Rs548234 polymorphism at PRDM1-ATG5 region susceptible to rheumatoid arthritis in Caucasians is not associated with rheumatoid arthritis in Chinese Han population[J].CHINESE MEDICAL JOURNAL.2011,124(18):2863-2867.doi:10.3760/cma.j.issn.0366-6999.2011.18.012.
APA:
LU Xiao-lan,ZHOU Xu-jie,GUO Jian-ping,JIA Ru-lin,ZHAO Yi...&LI Zhan-guo.(2011).Rs548234 polymorphism at PRDM1-ATG5 region susceptible to rheumatoid arthritis in Caucasians is not associated with rheumatoid arthritis in Chinese Han population.CHINESE MEDICAL JOURNAL,124,(18)
MLA:
LU Xiao-lan,et al."Rs548234 polymorphism at PRDM1-ATG5 region susceptible to rheumatoid arthritis in Caucasians is not associated with rheumatoid arthritis in Chinese Han population".CHINESE MEDICAL JOURNAL 124..18(2011):2863-2867