Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer's disease in the Han Chinese population
机构：[1]Department of Neurology, Inner Mongolia People 's Hospital, Huhhot 010017, Inner Mongolia Autonomous Region, China[2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院[3]Inner Mongolia Corps Hospital, Chinese People 's Armed Police Forces, Huhhot O10040, Inner Mongolia Autonomous Region, China
A missense C/T polymorphism in exon 6 (the NCBI rsID is rs2227564) of the urokinase-type plasminogen activator gene has been identified as a possible hot spot for Alzheimer's disease risk. The present study analyzed urokinase-type plasminogen gene polymorphisms of rs2227564 with sporadic Alzheimer's disease by PCR-restriction fragment length polymorphism. Results showed that CC, CT and IT genotype distribution frequencies had significant differences between sporadic Alzheimer's disease patients and healthy controls. In-depth analysis of the association between urokinase-type plasminogen gene rs2227564 polymorphisms and sporadic Alzheimer's disease indicated that people with the C-positive genotype CC + CT were at a higher risk for developing sporadic Alzheimer's disease. These results support the contribution of the polymorphisms of rs2227564 in the urokinase-type plasminogen gene to the pathogenesis of sporadic Alzheimer's disease in the Han Chinese population.
基金：
the NationalNatural Science Foundation of China( No. 30470615)
第一作者机构：[1]Department of Neurology, Inner Mongolia People 's Hospital, Huhhot 010017, Inner Mongolia Autonomous Region, China
通讯作者：
通讯机构：[*1]Department of Neurology,Xuanwu Hospital, Capital Medical University, Beijing100053, China
推荐引用方式(GB/T 7714)：
Xuelian Ji,Longfei Jia,Jianping Jia,et al.Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer's disease in the Han Chinese population[J].NEURAL REGENERATION RESEARCH.2012,7(30):2377-2383.doi:10.3969/j.issn.1673-5374.2012.30.008.
APA：
Xuelian Ji,Longfei Jia,Jianping Jia&Li Qi.(2012).Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer's disease in the Han Chinese population.NEURAL REGENERATION RESEARCH,7,(30)
MLA：
Xuelian Ji,et al."Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer's disease in the Han Chinese population".NEURAL REGENERATION RESEARCH 7..30(2012):2377-2383
