机构：[a]Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Xuanwu District, Beijing 100053, China神经内科首都医科大学宣武医院[b]Key Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing, China[c]The Department of Neurology, Affiliated with the Zhongda Hospital of Southeast University and The Institute of Neuropsychiatry of Southeast University, Nanjing, China
The deposition of amyloid beta peptides (A beta) in the brain is crucial in the pathogenesis of Alzheimer's disease (AD). A disintegrin and metalloproteinase (ADAM) 17 cleaves the amyloid precursor protein (APP) within the A beta sequence and, therefore, precludes the formation of neurotoxic A beta. To explore the correlation between the ADAM17 promoter and sporadic AD (SAD), a case-control study was conducted in a Northern Chinese Han population. The ADAM 17 gene promoter region was screened, resulting in five known and one novel single nucleotide polymorphisms (SNP): -1672C/T (rs11689958), -1638T/G (rs1524668), -1437T/C (rs11684747), -1333C/T (rs12474969), -172T/C (rs12692386) and -154C/A. Using direct sequencing, genotypes were determined in 403 patients who had SAD and 323 control participants. No association was observed between these polymorphisms and SAD. These data indicated that, in a Northern Chinese Han population, SNP in the ADAM17 promoter do not influence the risk of SAD. (C) 2010 Elsevier Ltd. All rights reserved.
基金：
National Key Technology R&D Program in the Eleventh Five-year Plan Period (2006BAI02B01);
the key project of the National Natural Science Foundation of China (30830045);
the National Basic Research 973 Program (2006CB500700);
the Beijing Natural Science Foundation (7071004), the National Natural Science foundation of China (30600656);
the New-Star Plan of Science and Technology of Beijing (2004B12);
and the Key Project of Science and Technology Plan of Beijing Municipal Education Commission (KZ200910025005).
第一作者机构：[a]Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Xuanwu District, Beijing 100053, China[b]Key Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing, China
通讯作者：
通讯机构：[a]Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Xuanwu District, Beijing 100053, China[b]Key Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing, China
推荐引用方式(GB/T 7714)：
Min Wang,Yang Li,Yan Lu,et al.The relationship between ADAM17 promoter polymorphisms and sporadic Alzheimer's disease in a Northern Chinese Han population[J].JOURNAL OF CLINICAL NEUROSCIENCE.2010,17(10):1276-1279.doi:10.1016/j.jocn.2010.01.008.
APA：
Min Wang,Yang Li,Yan Lu,Xiumei Zuo,Fen Wang...&Jianping Jia.(2010).The relationship between ADAM17 promoter polymorphisms and sporadic Alzheimer's disease in a Northern Chinese Han population.JOURNAL OF CLINICAL NEUROSCIENCE,17,(10)
MLA：
Min Wang,et al."The relationship between ADAM17 promoter polymorphisms and sporadic Alzheimer's disease in a Northern Chinese Han population".JOURNAL OF CLINICAL NEUROSCIENCE 17..10(2010):1276-1279
