机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China[2]Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China[3]Department of Nephrology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China[4]Department of Clinical Laboratory, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China[5]Department of Central Laboratory, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China[6]Department of Emergency and Rescue Medicine, Xuzhou Medical University, Xuzhou, Jiangsu Province, China[7]Department of Neurosurgical Intensive Care Unit, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China[8]Department of Blood Supply, Yantai Center Blood Station, Yantai, Shandong Province, China
Stem cell transplantation has brought new hope for the treatment of neurological diseases. The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells. Because the differentiation of stem cells in vitro and in vivo is affected by multiple factors, the final differentiation outcome is strongly associated with the microenvironment in which the stem cells are located. Accordingly, the optimal microenvironment for inducing stem cell differentiation is a hot topic. EGb761 is extracted from the leaves of the Ginkgo biloba tree. It is used worldwide and is becoming one of the focuses of stem cell research. Studies have shown that EGb761 can antagonize oxygen free radicals, stabilize cell membranes, promote neurogenesis and synaptogenesis, increase the level of brain-derived neurotrophic factors, and replicate the environment required during the differentiation of stem cells into nerve cells. This offers the possibility of using EGb761 to induce the differentiation of stem cells, facilitating stem cell transplantation. To provide a comprehensive reference for the future application of EGb761 in stem cell therapy, we reviewed studies investigating the influence of EGb761 on stem cells. These started with the composition and neuropharmacology of EGb761, and eventually led to the finding that EGb761 and some of its important components play important roles in the differentiation of stem cells and the protection of a beneficial microenvironment for stem cell transplantation.
基金：
National Natural Science Foundation of China [81501185]; Key Research & Development Project of Shandong Province of China [2017GSF218043]; Science and Technology Planning Project of Yantai of China [2016WS017, 2017WS105]
第一作者机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China[2]Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China[2]Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China[6]Department of Emergency and Rescue Medicine, Xuzhou Medical University, Xuzhou, Jiangsu Province, China[7]Department of Neurosurgical Intensive Care Unit, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China
推荐引用方式(GB/T 7714)：
Chao Ren,Yong-Qiang Ji,Hong Liu,et al.Effects of Ginkgo biloba extract EGb761 on neural differentiation of stem cells offer new hope for neurological disease treatment[J].NEURAL REGENERATION RESEARCH.2019,14(7):1152-1157.doi:10.4103/1673-5374.251191.
APA：
Chao Ren,Yong-Qiang Ji,Hong Liu,Zhe Wang,Jia-Hui Wang...&Pei-Yuan Yin.(2019).Effects of Ginkgo biloba extract EGb761 on neural differentiation of stem cells offer new hope for neurological disease treatment.NEURAL REGENERATION RESEARCH,14,(7)
MLA：
Chao Ren,et al."Effects of Ginkgo biloba extract EGb761 on neural differentiation of stem cells offer new hope for neurological disease treatment".NEURAL REGENERATION RESEARCH 14..7(2019):1152-1157
