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Induced pluripotent stem cell-derived mesenchymal stem cells enhance acellular nerve allografts to promote peripheral nerve regeneration by facilitating angiogenesis

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Pubmed体系：

收录情况： ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：梯队期刊

作者：
Meng Fan-Qi[1,2,3,4] * ; Li Chao-Chao[2,5,3] * ; Xu Wen-Jing[2] ; Deng Jun-Hao[5,6] ; Guan Yan-Jun[2] ; Zhang Tie-Yuan[2] ; Yang Bo-Yao[2] ; Zhang Jian[2] ; Li Xiang-Ling[2] ; Han Feng[2] ; Ren Zhi-Qi[2] ; Xu Shuai[1] ; Liang Yan[1] ; Jiang Wen[7,8] ; Peng Jiang[1,2,5,3] ; Wang Yu[1,2,5,3] ; Liu Hai-Ying[1] ;
机构： [1]Department of Spine Surgery, Peking University People's Hospital, Beijing, China. [2]Beijing Key Lab of Regenerative Medicine in Orthopedics, Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China. [3]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China. [4]Department of Anesthesiology, Capital Medical University Xuanwu Hospital, Beijing, China. [5]Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China. [6]National Clinical Research Center for Orthopedics, Beijing, China. [7]Department of Orthopedics, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, China. [8]Department of Pain Treatment, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, China.
出处：
DOI： 10.4103/NRR.NRR-D-22-00311
ISSN：

关键词： acellular nerve allograft angiogenesis bioluminescence imaging conditioned medium induced pluripotent stem cell–derived mesenchymal stem cells micro-CT scanning Microfil perfusion peripheral nerve injury

摘要：
Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells. However, adult tissue-derived mesenchymal stem cells encounter various obstacles, including limited tissue sources, invasive acquisition methods, cellular heterogeneity, purification challenges, cellular senescence, and diminished pluripotency and proliferation over successive passages. In this study, we used induced pluripotent stem cell-derived mesenchymal stem cells, known for their self-renewal capacity, multilineage differentiation potential, and immunomodulatory characteristics. We used induced pluripotent stem cell-derived mesenchymal stem cells in conjunction with acellular nerve allografts to address a 10 mm-long defect in a rat model of sciatic nerve injury. Our findings reveal that induced pluripotent stem cell-derived mesenchymal stem cells exhibit survival for up to 17 days in a rat model of peripheral nerve injury with acellular nerve allograft transplantation. Furthermore, the combination of acellular nerve allograft and induced pluripotent stem cell-derived mesenchymal stem cells significantly accelerates the regeneration of injured axons and improves behavioral function recovery in rats. Additionally, our in vivo and in vitro experiments indicate that induced pluripotent stem cell-derived mesenchymal stem cells play a pivotal role in promoting neovascularization. Collectively, our results suggest the potential of acellular nerve allografts with induced pluripotent stem cell-derived mesenchymal stem cells to augment nerve regeneration in rats, offering promising therapeutic strategies for clinical translation.Copyright © 2025 Copyright: © 2025 Neural Regeneration Research.

基金：
National Natural Science Foundation of China, No. 32171356 ; Self-Support Research Projects of Shihezi University, No. ZZZC2021105, Capital Medical University Natural Science Cultivation Fund, No. PYZ23044 , Beijing Municipal Natural Science Foundation, No.7244410 .
语种：
外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 3 区 细胞生物学 3 区 神经科学
最新[2023]版：
大类 | 2 区 医学
小类 | 3 区 细胞生物学 3 区 神经科学
第一作者：
第一作者机构： [1]Department of Spine Surgery, Peking University People's Hospital, Beijing, China. [2]Beijing Key Lab of Regenerative Medicine in Orthopedics, Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China. [3]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China. [4]Department of Anesthesiology, Capital Medical University Xuanwu Hospital, Beijing, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Spine Surgery, Peking University People's Hospital, Beijing, China. [2]Beijing Key Lab of Regenerative Medicine in Orthopedics, Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China. [3]Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China. [5]Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.
推荐引用方式(GB/T 7714)：
Meng Fan-Qi,Li Chao-Chao,Xu Wen-Jing,et al.Induced pluripotent stem cell-derived mesenchymal stem cells enhance acellular nerve allografts to promote peripheral nerve regeneration by facilitating angiogenesis[J].Neural Regeneration Research.2024,doi:10.4103/NRR.NRR-D-22-00311.
APA：
Meng Fan-Qi,Li Chao-Chao,Xu Wen-Jing,Deng Jun-Hao,Guan Yan-Jun...&Liu Hai-Ying.(2024).Induced pluripotent stem cell-derived mesenchymal stem cells enhance acellular nerve allografts to promote peripheral nerve regeneration by facilitating angiogenesis.Neural Regeneration Research,,
MLA：
Meng Fan-Qi,et al."Induced pluripotent stem cell-derived mesenchymal stem cells enhance acellular nerve allografts to promote peripheral nerve regeneration by facilitating angiogenesis".Neural Regeneration Research .(2024)

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