机构：[1]Department of Otolaryngology, the Second Affiliated Hospital of Soochow University, Soochow University[2]College of Textiles and Clothing Engineering, Soochow University, National Engineering Laboratory for Modern Silk[3]Department of Cell Biology, Medical College of Soochow University, Jiangsu Province Key Laboratory of Stem Cell Research[4]Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou Jiangsu People’s Republic of China
Objective: To study whether regenerated electrospun silk fibroin (SF) nanofibers as nerve conduits could improve nerve regeneration microenvironment and induce the facial nerve regeneration of Sprague-Dawley rats. Design: Electrospun SF nanofibers were prepared to bridge a 5-mm facial nerve defect in Sprague-Dawley rats. Three months after implantation, a comprehensive morphologic and functional evaluation was performed by electrophysiology, histology, Fluorogold retrograde tracing, and transmission electron micrograph. Results: The SF nanofiber tube exhibited good biocompatibility in vivo, and no distinct regional inflammation response and scar formation was observed. After 3 months of operation, the morphologic and functional investigation has shown a positive evaluation on the nerve repair outcome elicited by SF nanofiber graft and autograft. Conclusion: Electrospun SF grafts could promote nerve regeneration after facial nerve injury and become a potential possibility of newly developed nerve grafts as an alternative of autografts to peripheral nerve regeneration.
基金：
The authors also thank the
National Natural Science Foundation of China (30870642 and
31071220), the Natural Science Foundation of Jiangsu Province
(BK2009119), the China Project 211, the Social Development
Foundation of Suzhou (SYS201034), and the Open Project Program
of Key Laboratory of Eco-Textiles, Ministry of Education,
Jiangnan University (KLET1005) for support of this work.
第一作者机构：[1]Department of Otolaryngology, the Second Affiliated Hospital of Soochow University, Soochow University
通讯作者：
通讯机构：[*1]Department of Cell Biology, Medical College of Soochow University,Jiangsu Province Key Laboratory of Stem Cell Research, Suzhou 215123, People’s Republic of China[*2]Department of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou Jiangsu 215006, People’s Republic of China
推荐引用方式(GB/T 7714)：
Aijun Hu ,Baoqi Zuo,Feng Zhang ,et al.Evaluation of Electronspun Silk Fibroin-Based Transplants Used for Facial Nerve Repair[J].OTOLOGY & NEUROTOLOGY.2013,34(2):311-8.doi:10.1097/MAO.0b013e31827b4bd4.
APA：
Aijun Hu,,Baoqi Zuo,Feng Zhang,,Huanxiang Zhang&Qing Lan.(2013).Evaluation of Electronspun Silk Fibroin-Based Transplants Used for Facial Nerve Repair.OTOLOGY & NEUROTOLOGY,34,(2)
MLA：
Aijun Hu,,et al."Evaluation of Electronspun Silk Fibroin-Based Transplants Used for Facial Nerve Repair".OTOLOGY & NEUROTOLOGY 34..2(2013):311-8
