机构：[1]Department of Otolaryngy, the Second Affiliated Hospital of Soochow University, Suzhou 215021, Jiangsu Province, China[2]College of Textiles and Clothing Engineering, Soochow University, Suzhou 215021, Jiangsu Province, China[3]National Engineering Laboratory for Modern Silk, Suzhou 215023, Jiangsu Province, China[4]Jiangsu Province Key Laboratory of Stem Cell Research, Medical College of Soochow University, Suzhou 215007, Jiangsu Province, China[5]Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
In this study, Schwann cells, at a density of 1 x 10(5) cells/well, were cultured on regenerated silk fibroin nanofibers (305 +/- 84 nm) prepared using the electrospinning method. Schwann cells cultured on the silk fibroin nanofibers appeared more ordered, their processes extended further, and they formed more extensive and complex interconnections. In addition, the silk fibroin nanofibers had no impact on the proliferation of Schwann cells or on the secretion of ciliary neurotrophic factor, brain-derived neurotrophic factor or nerve growth factor. These findings indicate that regenerated electrospun silk fibroin nanofibers can promote Schwann cell adhesion, growth and proliferation, and have excellent biocompatibility.
基金：
Social Development Foundation of Suzhou, No. SYS201034, and the Open Project Program of Key Laboratory of Eco-Textiles, Ministry of Education, Jiangnan University, No. KLET1005.
第一作者机构：[1]Department of Otolaryngy, the Second Affiliated Hospital of Soochow University, Suzhou 215021, Jiangsu Province, China
通讯作者：
通讯机构：[*1]Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China[*2]Jiangsu Province Key Laboratory of Stem Cell Research, Medical College of Soochow University, Suzhou 215007, Jiangsu Province, China
推荐引用方式(GB/T 7714)：
Aijun Hu ,Baoqi Zuo ,Feng Zhang ,et al.Electrospun silk fibroin nanofibers promote Schwann cell adhesion, growth and proliferation[J].NEURAL REGENERATION RESEARCH.2012,7(15):1171-8.doi:10.3969/j.issn.1673-5374.2012.15.008.
