机构：[1]Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Oncology, The Second Peoples Hospital of Hefei, Hefei, People’s Republic of China[3]State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, China[4]Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, China
There is a pressing need to establish automated solutions for the rapid, high-throughput, and automatic detection of chromosome aberrations (CAs) in the occupational health surveillance of large-scale radiation workers. Here, we described and verified the accuracy of a new measurement system based on the automatic scanning and analysis of dicentric chromosomes (DICs). The effects of cell number on DIC detection by automatic scanning and analysis were studied, and the distribution of DIC values per cell was calculated. In total, 1088 cases were detected by automatic DIC scanning and analysis in 26 663 radiation workers, and 73 cases were further confirmed by a technician, including 5 cases in which radiation exposure lead to harmful medical consequences. Our approach reduces the workload by 96% and increases the speed of assessment approximately 7-fold. Overall, this study validates the utility of a novel rapid and high-throughput CA detection procedure as a means of occupational health surveillance of large-scale radiation workers.
基金：
Jiangsu Health and Family Planning Commission Preventive Medicine Research Projects in 2014-2015 [Y2015024]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|3 区核医学4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区药学4 区核医学
JCR分区：
出版当年[2017]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3PHARMACOLOGY & PHARMACY
最新[2024]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Oncology, The Second Peoples Hospital of Hefei, Hefei, People’s Republic of China
通讯作者：
通讯机构：[1]Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Oncology, The Second Peoples Hospital of Hefei, Hefei, People’s Republic of China
推荐引用方式(GB/T 7714)：
Bi Jinling,Dai Hong,Feng Junchao,et al.Rapid and High-Throughput Detection of Peripheral Blood Chromosome Aberrations in Radiation Workers[J].DOSE-RESPONSE.2019,17(2):1559325819840852.doi:10.1177/1559325819840852.
APA：
Bi, Jinling,Dai, Hong,Feng, Junchao,Bian, Huahui,Chen, Weibo...&Huang, Yong.(2019).Rapid and High-Throughput Detection of Peripheral Blood Chromosome Aberrations in Radiation Workers.DOSE-RESPONSE,17,(2)
MLA：
Bi, Jinling,et al."Rapid and High-Throughput Detection of Peripheral Blood Chromosome Aberrations in Radiation Workers".DOSE-RESPONSE 17..2(2019):1559325819840852
