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Rapid and High-Throughput Detection of Peripheral Blood Chromosome Aberrations in Radiation Workers

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机构: [1]Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China [2]Department of Oncology, The Second Peoples Hospital of Hefei, Hefei, People’s Republic of China [3]State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, China [4]Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, China
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关键词: high-throughput automatic dicentric chromosome analysis radiation workers occupational health surveillance

摘要:
There is a pressing need to establish automated solutions for the rapid, high-throughput, and automatic detection of chromosome aberrations (CAs) in the occupational health surveillance of large-scale radiation workers. Here, we described and verified the accuracy of a new measurement system based on the automatic scanning and analysis of dicentric chromosomes (DICs). The effects of cell number on DIC detection by automatic scanning and analysis were studied, and the distribution of DIC values per cell was calculated. In total, 1088 cases were detected by automatic DIC scanning and analysis in 26 663 radiation workers, and 73 cases were further confirmed by a technician, including 5 cases in which radiation exposure lead to harmful medical consequences. Our approach reduces the workload by 96% and increases the speed of assessment approximately 7-fold. Overall, this study validates the utility of a novel rapid and high-throughput CA detection procedure as a means of occupational health surveillance of large-scale radiation workers.

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出版当年[2018]版:
大类 | 4 区 医学
小类 | 3 区 核医学 4 区 药学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 药学 4 区 核医学
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出版当年[2017]版:
Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q3 PHARMACOLOGY & PHARMACY
最新[2024]版:
Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q3 PHARMACOLOGY & PHARMACY

影响因子: 最新[2024版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

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第一作者机构: [1]Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China [2]Department of Oncology, The Second Peoples Hospital of Hefei, Hefei, People’s Republic of China
通讯作者:
通讯机构: [1]Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China [2]Department of Oncology, The Second Peoples Hospital of Hefei, Hefei, People’s Republic of China
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