机构：[a]Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China[b]Department of Radiation, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China[c]Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China[d]Department of Neurosurgery, Wuxi No.2 Hospital Affiliated to Nanjing Medical University, Wuxi, China[e]Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Long non-coding RNAs (lncRNAs) play vital roles in the pathobiology of glioblastoma multiforme (GBM). Though radiotherapy remains the most effective component of multiple therapies for patients with GBM, lncRNAs conferring GBM radioresistance are less unknown. Here, the present study identified that the antisense transcript of hypoxia-inducible factor-1 alpha (AHIF) was upregulated in GBM cells after radiotherapy. The deregulation of AHIF affected GBM cell clonogenic formation, DNA repair and apoptosis. Notably, knockdown of AHIF inhibited tumorigenesis after radiotherapy in vivo. Further biochemical analysis identified that AHIF regulated proteins associated with apoptosis after radiotherapy. Thus, the present data illustrate that suppression of AHIF increases radiosensitivity in GBM cells, which may be a potential diagnostic and therapeutic target for GBM patients. (C) 2018 Elsevier Inc. All rights reserved.
基金：
Incubating Program for Clinical Research and Innovation of Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University [PYXJS16-005]; National Natural Science Foundation of China [81671203]
第一作者机构：[a]Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Radiation, Renji Hospital, School of Medicine, Shanghai Jiaotong University, First Floor, Building 3, 1630 Dongfang Road, Pudong District, Shanghai, China.[*2]Department of neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Room 118, Building 11, 1630 Dongfang Road, Pudong District, Shanghai, China.
推荐引用方式(GB/T 7714)：
Keman Liao,Xiumei Ma,Binghong Chen,et al.Upregulated AHIF-mediated radioresistance in glioblastoma[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2019,509(2):617-623.doi:10.1016/j.bbrc.2018.12.136.
APA：
Keman Liao,Xiumei Ma,Binghong Chen,Xiaojie Lu,Yaomin Hu...&Yongming Qiu.(2019).Upregulated AHIF-mediated radioresistance in glioblastoma.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,509,(2)
MLA：
Keman Liao,et al."Upregulated AHIF-mediated radioresistance in glioblastoma".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 509..2(2019):617-623
