Evaluation of the prognostic value of surgery and postoperative radiotherapy for patients with thymic neuroendocrine tumors: A propensity-matched study based on the SEER database
机构：[1]Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China[2]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China[3]Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China[4]Department of Thoracic Surgery, The Second Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou, China
Background The prognostic value of surgery and postoperative radiotherapy (PORT) for primary thymic neuroendocrine tumors (TNETs) was estimated using the SEER database. Methods This retrospective study used SEER data of TNET patients between 1998 and 2015. Propensity score matching (PSM) was performed according to whether surgery was performed. The prognostic effects on overall survival (OS) and cancer-specific survival (CSS) were evaluated using multivariate Cox regression. Results A total of 3947 patients were included: 293 (7.4%) TNET, 2788 (70.6%) thymoma, and 866 (21.9%) thymic carcinoma. Compared to other subtypes, TNET patients were younger, included a larger proportion of men, had a well or moderately differentiated histological grade, higher disease stage at diagnosis, and were more likely to have regional lymph node metastasis. The median OS and CSS for TNET were 82.9 (95% confidence interval 74.3-91.4) and 101.9 (95% confidence interval 91.9-111.8) months, respectively, significantly shorter than for thymomas. In the matched cohort of TNET patients, multivariate analysis of OS and CSS revealed a significantly poorer prognosis in the non-surgery group (P < 0.001). Compared to total/radical resection, TNET patients who underwent debulking resection had significantly inferior outcomes (P < 0.05). Postoperative radiotherapy favorably impacted OS and CSS in Masaoka-Koga stage III-IV TNET patients; this OS impact was also observed in stage IIB patients. Conclusion TNETs are extremely rare with relatively dismal outcomes. This analysis revealed the role of complete surgical resection and the favorable effect of postoperative radiotherapy in specific TNET subgroups.
第一作者机构：[1]Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China[2]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Radiation Oncology, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, Shanghai 200032, China.
推荐引用方式(GB/T 7714)：
Junmiao Wen,Jiayan Chen,Donglai Chen,et al.Evaluation of the prognostic value of surgery and postoperative radiotherapy for patients with thymic neuroendocrine tumors: A propensity-matched study based on the SEER database[J].THORACIC CANCER.2018,9(12):1603-1613.doi:10.1111/1759-7714.12868.
APA：
Junmiao Wen,Jiayan Chen,Donglai Chen,Di Liu,Xinyan Xu...&Yongbing Chen.(2018).Evaluation of the prognostic value of surgery and postoperative radiotherapy for patients with thymic neuroendocrine tumors: A propensity-matched study based on the SEER database.THORACIC CANCER,9,(12)
MLA：
Junmiao Wen,et al."Evaluation of the prognostic value of surgery and postoperative radiotherapy for patients with thymic neuroendocrine tumors: A propensity-matched study based on the SEER database".THORACIC CANCER 9..12(2018):1603-1613
