机构：[1]Department of Neurology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou, China[2]Institute of Neuroscience, Soochow University, Suzhou, China[3]Laboratory of Neurological Diseases, Department of Neurology, Changzhou No. 2 People’s Hospital, The Affiliated Hospital of Nanjing Medical University, 29 Xinglong Alley, Changzhou, China
Objectives The serum concentration of brain-derived neurotrophic factor (BDNF) was compared among patients with Parkinson's disease (PD), patients with essential tremor (ET), and healthy participants, and its association with clinical features of PD and ET was assessed. Methods Demographic and clinical data were collected from 60 patients with PD at different clinical stages, 60 patients with ET, and 60 controls. All participants' serum BDNF concentrations were measured. Their motor abilities and activity were assessed by the Unified PD Rating Scale and the Hoehn and Yahr (H-Y) staging scale. Results Serum BDNF was significantly lower in patients with PD than in patients with ET and controls. BDNF decreased only in the early disease stages (H-Y stages I and II), but increased markedly in the advanced stages (H-Y stages III-V). There was no significant difference between patients with ET and controls. The BDNF concentration was negatively correlated with age at PD onset and positively associated with disease duration, severity of PD symptoms, and treatment with L-DOPA. Conclusions A low serum BDNF concentration may serve as a biomarker in the early stages of PD, whereas a high concentration with PD progression may be due to treatment with L-DOPA in the advanced stages.
基金：
This work was supported by the National
Natural Science Foundation of China (no.
81200970 to Y.H. and No. 81471338 to X.Z.),
a Changzhou Sci & Tech Program Grant
(CJ20130046 to Y.H. and CE20145045 to
X.Z.), and the Changzhou High-Level Medical
Talents Training Project (No. 2016CZBJ023 to
Y.H. and No. 2016CZLJ018 to X.Z.).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2016]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Neurology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou, China
通讯作者：
通讯机构：[1]Department of Neurology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou, China
推荐引用方式(GB/T 7714)：
Yixian Huang,Wenwei Yun,Min Zhang,et al.Serum concentration and clinical significance of brain-derived neurotrophic factor in patients with Parkinson's disease or essential tremor[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2018,46(4):1477-1485.doi:10.1177/0300060517748843.
APA：
Yixian Huang,Wenwei Yun,Min Zhang,Weifeng Luo&Xianju Zhou.(2018).Serum concentration and clinical significance of brain-derived neurotrophic factor in patients with Parkinson's disease or essential tremor.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,46,(4)
MLA：
Yixian Huang,et al."Serum concentration and clinical significance of brain-derived neurotrophic factor in patients with Parkinson's disease or essential tremor".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 46..4(2018):1477-1485
