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Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential.

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收录情况： ◇ SCIE ◇ 卓越：重点期刊

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机构： [1]Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, College of Pharmacy, Jining Medical University, Jining 272067, Shandong, China [2]Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada [3]National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [4]Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, School of Mental Health and The Afliated Kangning Hospital, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China [5]Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou 325001, Zhejiang, China

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关键词： Brain-derived neurotrophic factor Alzheimer’s disease Amyloid β protein Tau protein Neuroinfammation Neuronal apoptosis

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Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to arise as the disease progresses. A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a mechanistic link between amyloid β (Aβ) and tau pathology and thus may serve as an obligatory relay of the cognitive impairment in AD. Brain-derived neurotrophic factors (BDNFs) play an important role in maintaining synaptic plasticity in learning and memory. Considering AD as a synaptic disorder, BDNF has attracted increasing attention as a potential diagnostic biomarker and a therapeutical molecule for AD. Although depletion of BDNF has been linked with Aβ accumulation, tau phosphorylation, neuroinflammation and neuronal apoptosis, the exact mechanisms underlying the effect of impaired BDNF signaling on AD are still unknown. Here, we present an overview of how BDNF genomic structure is connected to factors that regulate BDNF signaling. We then discuss the role of BDNF in AD and the potential of BDNF-targeting therapeutics for AD.© 2022. The Author(s).

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医学

小类 | 1 区神经科学

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大类 | 1 区医学

小类 | 1 区神经科学

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Q1 NEUROSCIENCES

影响因子： 10.8 最新[2023版] 11.6 最新五年平均 8.014 出版当年[2020版] 9.033 出版当年五年平均 5.551 出版前一年[2019版] 9.883 出版后一年[2021版]

第一作者：

第一作者机构： [1]Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, College of Pharmacy, Jining Medical University, Jining 272067, Shandong, China [2]Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada

通讯作者：

通讯机构： [1]Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, College of Pharmacy, Jining Medical University, Jining 272067, Shandong, China [2]Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada [3]National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [4]Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, School of Mental Health and The Afliated Kangning Hospital, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China [5]Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou 325001, Zhejiang, China

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Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential.