机构：[1]School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China[2]Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China[3]Medical College of Soochow University, Suzhou 215123, China[4]The Second Affiliated Hospital of Soochow University, Suzhou 215123, China[5]Center for Radiological Research, College of Physician and Surgeons, Columbia University, New York, NY 10032, USA
Cancer cells usually utilize glucose as a carbon source for aerobic glycolysis, a phenomenon known as the Warburg effect. And a high rate of glycolysis has been observed in lung cancer cells. The growing evidence indicates that long non-coding RNAs (lncRNAs) are important players in lung cancer initiation and progression. However, the correlation between lncRNAs and glycolysis remains unclear. In this study, we recognized a lncRNA, LNC CRYBG3, which can interact with lactate dehydrogenase A (LDHA), a vital enzyme of glycolysis, is highly upregulated in both clinical lung cancer tissues and in vitro cultured lung cancer cell lines. A positive correlation between the expression level of LNC CRYBG3 and LDHA expression levels is observed. In another hand, LNC CRYBG3 is a regulator of glycolysis and its overexpression promoted the uptake of glucose and the production of lactate whereas the knockdown of LNC CRYBG3 led to opposite results and suppressed cell proliferation. These results indicated that LNC CRYBG3 might be a novel target for lung cancer treatment.
基金：
This work was
supported by the National Natural Science Foundations
of China (No. 11335011, 11405235, 81602794,
U1432117 and U1432124), China Postdoctoral Science
Foundation (2017T100399), Jiangsu Postdoctoral
Science Foundation (1701176B), Jiangsu Science
Foundation (BK20160334), Collaborative Innovation
Center of Radiological Medicine of Jiangsu Higher
Education Institutions and A Project Funded by the
Priority Academic Program Development of Jiangsu
Higher Education Institutions (PAPD).
第一作者机构：[1]School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China[2]Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China
共同第一作者：
通讯作者：
通讯机构：[*1]199 Renai Road, Suzhou 215123, China
推荐引用方式(GB/T 7714)：
Huaiyuan Chen,Hailong Pei,Wentao Hu,et al.Long non-coding RNA CRYBG3 regulates glycolysis of lung cancer cells by interacting with lactate dehydrogenase A[J].JOURNAL OF CANCER.2018,9(14):2580-2588.doi:10.7150/jca.24896.
APA：
Huaiyuan Chen,Hailong Pei,Wentao Hu,Ji Ma,Jian Zhang...&Guangming Zhou.(2018).Long non-coding RNA CRYBG3 regulates glycolysis of lung cancer cells by interacting with lactate dehydrogenase A.JOURNAL OF CANCER,9,(14)
MLA：
Huaiyuan Chen,et al."Long non-coding RNA CRYBG3 regulates glycolysis of lung cancer cells by interacting with lactate dehydrogenase A".JOURNAL OF CANCER 9..14(2018):2580-2588
