机构：[1]Center of Translational Medicine, The First People Hospital of Zhangjiagang City, Soochow University, Suzhou, China[2]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China[3]Institute of Neuroscience, Soochow University, Suzhou, China[4]Department of Otolaryngology, The First People Hospital of Zhangjiagang City, Soochow University, Suzhou, China
TBX2 is a member of the T box transcription factor family. Its expression and potential biological functions in nasopharyngeal cancer (NPC) cells are studied here. We showed that TBX2 mRNA and protein expression was significantly elevated in multiple human NPC tissues, as compared with that in adjacent normal tissues. Knockdown of TBX2 by targeted-siRNA significantly inhibited proliferation and invasion of NPC cells (CNE-1 and HONE-1 lines). Meanwhile, TBX2 knockdown also induced G1-phase cell cycle arrest. At the molecular level, we discovered that expressions of several tumor suppressor genes, including p21, p27, phosphatase with tensin homology (PTEN) and E-Cadherin, were increased dramatically after TBX2 knockdown in above NPC cells. Collectively, our results imply that TBX2 overexpression promotes NPC cell proliferation and invasion, possibly via silencing several key tumor suppressor genes.
基金：
This work is partly supported by the Youth Foundation of “Revitalize and Defend the Key Talent’s Subsidy Project” from the Science and Education Department of Health and Family Planning of Suzhou (KJXW2015042), by the Jiangsu University Special Program of Medical Science(JLY20160114), by the grants from the National Natural Science Foundation of China (Nos. 81302195, 31371139, 81571282, 81502162), and grants from Natural Science Foundation of Jiangsu Province (BK20130301), and the National Key Research and Development Program of China (2016YFC1302200).
第一作者机构：[1]Center of Translational Medicine, The First People Hospital of Zhangjiagang City, Soochow University, Suzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Center of Translational Medicine, The First People Hospital of Zhangjiagang City, Soochow University, Suzhou, China[3]Institute of Neuroscience, Soochow University, Suzhou, China[4]Department of Otolaryngology, The First People Hospital of Zhangjiagang City, Soochow University, Suzhou, China
推荐引用方式(GB/T 7714)：
Yan Lv,Meng Si,Nannan Chen,et al.TBX2 over-expression promotes nasopharyngeal cancer cell proliferation and invasion[J].ONCOTARGET.2017,8(32):52699-52707.doi:10.18632/oncotarget.17084.
APA：
Yan Lv,Meng Si,Nannan Chen,Ya Li,Xingkai Ma...&C. Cao.(2017).TBX2 over-expression promotes nasopharyngeal cancer cell proliferation and invasion.ONCOTARGET,8,(32)
MLA：
Yan Lv,et al."TBX2 over-expression promotes nasopharyngeal cancer cell proliferation and invasion".ONCOTARGET 8..32(2017):52699-52707
医学