详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Circular RNA hsa_circ_0008344 regulates glioblastoma cell proliferation, migration, invasion, and apoptosis

文献详情

资源类型：

收录情况： ◇ SCIE

作者：

机构： [1]Wuxi Clinical College of Anhui Medical University, Wuxi, China [2]Department of Neurosurgery, Wuxi PLA 101 Hospital, Wuxi, China [3]Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China [4]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

出处：

DOI：

ISSN：

关键词： apoptosis glioblastoma hsa_circ_0008344 invasion proliferation

摘要：

BackgroundRecent studies have found circular RNAs (circRNAs) involved in the biological process of cancers. However, little is known about their functional roles in glioblastoma. MethodsHuman circRNA microarray analysis was performed to screen the expression profile of circRNAs in IDH1 wild-type glioblastoma tissue. The expression of hsa_circ_0008344 in glioblastoma and normal brain samples was quantified by qRT-PCR. Functional experiments were performed to investigate the biological functions of hsa_circ_0008344, including MTT assay, colony formation assay, transwell assay, and cell apoptosis assay. ResultsCircRNA microarray revealed a total of 417 abnormally expressed circRNAs (>1.5-fold, P<.05) in glioblastoma tissue compared with the adjacent normal brain. Hsa_circ_0008344, among the top differentially expressed circRNAs, was significantly upregulated in IDH1 wild-type glioblastoma. Further in vitro studies showed that knockdown of hsa_circ_0008344 suppressed glioblastoma cell proliferation, colony formation, migration, and invasion, but increased cell apoptotic rate. ConclusionsHsa_circ_0008344 is upregulated in glioblastoma and may contribute to the progression of this malignancy.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区医学实验技术

最新[2025]版：

大类 | 4 区医学

小类 | 3 区医学实验技术

JCR分区：

出版当年[2016]版：

Q3 MEDICAL LABORATORY TECHNOLOGY

最新[2023]版：

Q2 MEDICAL LABORATORY TECHNOLOGY

影响因子： 2.6 最新[2023版] 2.4 最新五年平均 1.521 出版当年[2016版] 1.438 出版当年五年平均 1.549 出版前一年[2015版] 1.303 出版后一年[2017版]

第一作者：

第一作者机构： [1]Wuxi Clinical College of Anhui Medical University, Wuxi, China [2]Department of Neurosurgery, Wuxi PLA 101 Hospital, Wuxi, China

共同第一作者：

通讯作者：

通讯机构： [1]Wuxi Clinical College of Anhui Medical University, Wuxi, China [2]Department of Neurosurgery, Wuxi PLA 101 Hospital, Wuxi, China [3]Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China [*1]Wuxi Clinical College of Anhui Medical University, Wuxi, China. [*2]Changzheng Hospital, Second Military Medical University, Shanghai, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]MicroRNA-377 inhibited proliferation and invasion of human glioblastoma cells by directly targeting specificity protein 1 [2]Expression of SPRR3 is associated with tumor cell proliferation and invasion in glioblastoma multiforme [3]BNIP1 inhibits cell proliferation, migration and invasion, and promotes apoptosis by mTOR in cervical cancer cells [4]MiR-219-5p对人脑成胶质细胞瘤恶性表型的影响 [5]Long non-coding RNA EPB41L4A-AS2 inhibited non-small cell lung cancer proliferation and invasion and promoted cell apoptosis [6]The novel anti-neuroblastoma agent PF403, inhibits proliferation and invasion in vitro and in brain xenografts [7]Downregulation of the long non-coding RNA taurine-upregulated gene 1 inhibits glioma cell proliferation and invasion and promotes apoptosis [8]Expression and function of miR-27b in human glioma [9]miR-1273h-5p suppresses CXCL12 expression and inhibits gastric cancer cell invasion and metastasis [10]斑蝥酸钠维生素B6注射液体外诱导胶质母细胞瘤U87凋亡作用