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Long non-coding RNA EPB41L4A-AS2 inhibited non-small cell lung cancer proliferation and invasion and promoted cell apoptosis

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收录情况： ◇ SCIE

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机构： [1]Department of Cardiothoracic Surgery, Taicang Affiliated Hospital of Soochow University, the First People's Hospital of Taicang, Taicang, China. [2]Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China.

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关键词： NSCLC LncRNA EPB41L4A-AS2 proliferation apoptosis invasion

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This research investigates the expression of lncRNA EPB41L4A-AS2 in non-small cell lung cancer (NSCLC) and evaluates its influence on the proliferation, invasion and apoptosis of NSCLC. A total of 56 NSCLC tissues and corresponding adjacent tissue was collected. Quantitative Reverse transcription polymerase chain reaction (qRT-PCR) evaluated the lncRNA EPB41L4A-AS2 expression level in tissues and cell lines, and proliferating cell nuclear antigen (PCNA) protein level was determined by western blot assay. CCK8 assay, EdU assay, flow cytometry (FCM) and transwell assay were performed to access cell proliferation, apoptosis and invasion. EPB41L4A-AS2 expression was significantly down-regulated in cancer tissues and cells compared with adjacent tissues and normal cells (p<0.05). After cells were transfected with pcDNA3.1-EPB41L4A-AS2, cell viability and PCNA protein level was decreased, and cells were arrested in the G0/G1 phase with a higher apoptosis rate. Transwell assay showed that over-expressed EPB41L4A-AS2 could reduce cells invasion ability. Low-level expression of EPB41L4A-AS2 is associated with poor survival in NSCLC and over-expression of lncRNA EPB41L4A-AS2 inhibits NSCLC cell proliferation and invasion and promotes cell apoptosis.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2016]版：

Q4 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 2 最新[2023版] 2 最新五年平均 1.871 出版当年[2016版] 1.772 出版当年五年平均 1.961 出版前一年[2015版] 1.696 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Cardiothoracic Surgery, Taicang Affiliated Hospital of Soochow University, the First People's Hospital of Taicang, Taicang, China.

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