机构：[1]Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Rheumatology, The Second Affiliated Hospital of Soochow University, Suzhou, China[3]Department of Cardiothoracic Surgery, Shanghai Chest Hospital, Shanghai, China[4]Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
BackgroundEsophageal cancer has a high mortality rate, particularly in Asia, and there are obvious racial differences in regard to incidence. The purpose of our study was to assess the genetic susceptibility of functional single nucleotide polymorphisms in flap endonuclease-1 (FEN1) in esophageal squamous cell carcinoma ESCC. MethodsClinical blood samples of 629 ESCC cases and 686 control samples were collected. The ligation detection reaction method was used to determine FEN1 rs174538 G>A genotypes. ResultsA significantly decreased risk of ESCC was associated with FEN1 rs174538 GA genotypes among patients under 63 years old. ConclusionsOur results suggest that functional polymorphism FEN1 rs174538 G>A might affect personal susceptibility to ESCC. This result provides a solid theoretical foundation for further clinical study using larger sample sizes.
基金：
We are grateful to the Young Teachers’ Natural Science Foundation
of Soochow University (SDY2013A34), Medical
Research Foundation of Jiangsu Provincial Bureau of Health
(No. H201314), Science and Technology Research foundation
of Suzhou Municipality (No. SYS201476, No. SYS2014095),
Medical Research Foundation of Jiangsu Provincial Health
and Family Planning Commission (No. H201521), The Natural
Science Foundation of Jiangsu Provincial (BK20161224)
for assistance with funding for this study.
第一作者机构：[1]Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Soochow University, No 1055 San Xiang Road, Suzhou, Jiangsu Province 215004 China.
推荐引用方式(GB/T 7714)：
Yonghua Sang,Lin Bo,Haiyong Gu,et al.Flap endonuclease-1 rs174538 G > A polymorphisms are associated with the risk of esophageal cancer in a Chinese population[J].THORACIC CANCER.2017,8(3):192-196.doi:10.1111/1759-7714.12422.
APA：
Yonghua Sang,Lin Bo,Haiyong Gu,Wengtao Yang&Yongbing Chen.(2017).Flap endonuclease-1 rs174538 G > A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.THORACIC CANCER,8,(3)
MLA：
Yonghua Sang,et al."Flap endonuclease-1 rs174538 G > A polymorphisms are associated with the risk of esophageal cancer in a Chinese population".THORACIC CANCER 8..3(2017):192-196
