Background Despite the prevalence of Streptococcus pneumoniae serotype 19A, the molecular characteristics of this serotype are yet to be fully elucidated. The aim of this study was therefore to determine the homology of the serotype 19A in China. Methods Pulsed-field gel electrophoresis and multilocus sequence typing were done to these forty-nine serotype 19A isolates to investigate the relationship between the strains prevalent in Beijing and other regions. Results From 1997 to 2006, the percentage of serotype 19A isolates increased. The susceptibility rate to penicillin and amoxicillin decreased and the resistance rate to cefuroxime increased. ST320 was the most prevalent ST, followed by ST3546. There were six new STs identified in our study. The serotype 19A strains were classified into six different pulsed-field gel electrophoresis (PFGE) patterns. ST320, which was associated with two different PFGE patterns (A and D), accounted for 32 isolates, and ST3546, which was associated with two PFGE patterns (B and E), accounted for eight isolates. Conclusions From 2003 onwards, ST320 was the most common ST and the rate of resistance to cefuroxime increased significantly. Further long-term surveys of Streptococcus pneumoniae serotype 19A are required to monitor ST prevalence and antimicrobial resistance in this important human pathogen. Chin Med J 2011;124(12):1769-1774
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30801259]; Beijing Guidance Teacher Technology Item of Excellent Doctorship Thesis [YB20091002502]
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children, Beijing 100045, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Natl Key Discipline Pediat,Minist Educ, Beijing 100045, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children, Beijing 100045, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Natl Key Discipline Pediat,Minist Educ, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Xue Lian,Yao Kai-hu,Yu Sang-jie,et al.Molecular epidemiology of serotype 19A Streptococcus pneumoniae isolated from children in Beijing, 1997-2006[J].CHINESE MEDICAL JOURNAL.2011,124(12):1769-1774.doi:10.3760/cma.j.issn.0366-6999.2011.12.002.
APA：
Xue Lian,Yao Kai-hu,Yu Sang-jie,Liu Zun-jie,Qian Jing...&Yang Yong-hong.(2011).Molecular epidemiology of serotype 19A Streptococcus pneumoniae isolated from children in Beijing, 1997-2006.CHINESE MEDICAL JOURNAL,124,(12)
MLA：
Xue Lian,et al."Molecular epidemiology of serotype 19A Streptococcus pneumoniae isolated from children in Beijing, 1997-2006".CHINESE MEDICAL JOURNAL 124..12(2011):1769-1774
