机构：[a]Key Laboratory of Gastroenterology and Hepatology, School of Medicine, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Ministry of Health, Renji Hospital, Shanghai Jiao Tong University,[b]Division of Gastroenterology and Hepatology, Shanghai People’s Armed Police Corps Hospital, Shanghai[c]Department of Endoscopy, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
Background and aims Targeted biopsy under the guidance of magnifying endoscopy with narrow band imaging (ME-NBI) has higher accuracy than endoscopic forceps biopsy (EFB) in the differential diagnosis of cancerous lesions from noncancerous lesions. The aims of this study were to validate diagnostic efficacy of targeted biopsy under the guidance of ME-NBI (MNTB) and further evaluate whether it is necessary to perform MNTB when combined with ME-NBI. Methods This study prospectively analyzed 211 gastric lesions of suspected cancerous tissues. The sensitivity, specificity, positive predictive value, and negative predictive value of EFB, ME-NBI, MNTB, EFB plus ME-NBI, and MNTB plus ME-NBI for the diagnosis of cancerous lesions were determined, respectively. The accuracy, sensitivity, specificity of EFB and MNTB, EFB plus ME-NBI, and MNTB plus ME-NBI were also compared, respectively. Results The accuracy, sensitivity, and specificity with 95% confidence intervals were 68.2% (61.4-74.4%), 62.3% (54.1-69.9%), 84.2% (71.6-92.1%) for EFB, 75.4% (68.9-80.9%), 72.7% (64.9-79.4%), 82.5% (69.6-90.8%) for MNTB, 76.8% (70.4-82.2%), 73.4% (65.5-80.0%), 86.0% (73.7-93.3%) for ME-NBI, 82.0% (76.0-86.8%), 85.7% (79.0-90.6%), 71.9% (58.3-82.6%) for EFB plus ME-NBI, 84.8% (79.1-89.3%), 89.6% (83.4-93.8%), and 71.9% (58.3-82.6%) for MNTB plus ME-NBI, respectively. The sensitivity of MNTB was significantly higher than that of EFB (P=0.048). There was no significant difference in the sensitivity (P=0.307), specificity (P=1.000), and accuracy (P=0.337) between EFB plus ME-NBI and MNTB plus ME-NBI. Conclusion Although MNTB has a higher diagnostic efficacy than EFB in the diagnosis of cancerous lesions, it may be not necessary to perform MNTB when combined with ME-NBI. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
基金：
This study was supported by Incubating
Program for Clinical Research and Innovation of Ren Ji
Hospital, School of Medicine, Shanghai Jiao Tong
University (Grant No. PYMDT-001).
第一作者机构：[a]Key Laboratory of Gastroenterology and Hepatology, School of Medicine, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Ministry of Health, Renji Hospital, Shanghai Jiao Tong University,
共同第一作者：
通讯作者：
通讯机构：[*1]Key Laboratory of Gastroenterology and Hepatology, School of Medicine, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Ministry of Health, Renji Hospital, Shanghai Jiao Tong University, 145 Middle Shandong Road, Shanghai 200001, China
推荐引用方式(GB/T 7714)：
Qing-Wei Zhang,Ying Zhou,Jing-Jing Zhang,et al.Role of targeted biopsy under magnifying endoscopy with narrow band imaging may be not necessary: a prospective diagnostic accuracy study[J].EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY.2017,29(4):414-422.doi:10.1097/MEG.0000000000000802.
APA：
Qing-Wei Zhang,Ying Zhou,Jing-Jing Zhang,Hai-Yan Li,Jie-Ying Song...&Xiao-Bo Li.(2017).Role of targeted biopsy under magnifying endoscopy with narrow band imaging may be not necessary: a prospective diagnostic accuracy study.EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,29,(4)
MLA：
Qing-Wei Zhang,et al."Role of targeted biopsy under magnifying endoscopy with narrow band imaging may be not necessary: a prospective diagnostic accuracy study".EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 29..4(2017):414-422
