机构：[1]Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China.[2]Department of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China[3]Department of Pathology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
Intrahepatic cholestasis of pregnancy (ICP) is a severe liver disease uniquely occurring during pregnancy. In this study we aimed to identify novel biomarker for the diagnosis of ICP in Chinese population. 50 healthy pregnant women, 50 mild ICP patients and 48 severe ICP patients were enrolled for this study. Liver function tests, including serum total bilirubin, direct bilirubin, alanine transaminase, aspartate aminotransferase and cholyglycine, were performed in all participants. After an overnight fast serum levels of total bile acids (TBA), matrix metalloproteinase (MMP)-2 and MMP-9 were measured, and their correlation with liver function tests were analyzed. The observed increase in serum TBA in ICP patients was not statistically significant which made it unreliable for diagnosis of ICP in Chinese population. On the other hand, both MMP-2 and MMP-9 serum levels exhibited a progressive and significant elevation in mild and severe ICP patients compared with healthy pregnant women, which also positively correlated with liver function tests. Serum levels of both MMP-2 and MMP-9 could be reliably used as laboratory abnormalities for accurate diagnosis and sensitive grading of ICP in Chinese population
基金：
This study was supported by the Research Committee
of Wuxi Maternity and Child Health Hospital Affiliated to
Nanjing Medical University, Wuxi Jiangsu Province, China;
Science and Technology Development Project of
Wuxi, Jiangsu Province, China (nos.CSE31N1428).
第一作者机构：[1]Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China.[2]Department of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China[*1]Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, No. 48 Huaishu Road, Wuxi 214002, Jiangsu, China[*2]Department of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215006, Jiangsu, China.
通讯作者：
通讯机构：[*1]Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, No. 48 Huaishu Road, Wuxi 214002, Jiangsu, China[*2]Department of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215006, Jiangsu, China.
推荐引用方式(GB/T 7714)：
Zhong Chen,Zongji Shen,Lingqing Hu,et al.Identification of Matrix Metalloproteinase-2 and 9 as Biomarker of Intrahepatic Cholestasis of Pregnancy[J].ANNALS OF HEPATOLOGY.2017,16(2):291-296.doi:10.5604/16652681.1231589.
APA：
Zhong Chen,Zongji Shen,Lingqing Hu,Mudan Lu&Yizhong Feng.(2017).Identification of Matrix Metalloproteinase-2 and 9 as Biomarker of Intrahepatic Cholestasis of Pregnancy.ANNALS OF HEPATOLOGY,16,(2)
MLA：
Zhong Chen,et al."Identification of Matrix Metalloproteinase-2 and 9 as Biomarker of Intrahepatic Cholestasis of Pregnancy".ANNALS OF HEPATOLOGY 16..2(2017):291-296
