机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[2]Institutes of Neuroscience, Soochow University, Suzhou 215123, China
Circadian rhythm is manifested by the behavioral and physiological changes from day to night, which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei (SCN) in the anterior hypothalamus, while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles, rest and activity cycles. Parkinson's disease (PD) exhibits diurnal fluctuations. Circadian dysfunction has been observed in PD patients and animal models, which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore, circadian therapies, including light stimulation, physical activity, dietary and social schedules, may be helpful for PD patients. However, the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD, focusing on the clinical symptom variations, molecular changes, as well as the available treatment options.
基金：
This review was supported by the National
Natural Science Foundation of China (81471299), Jiangsu Provincial
Special Program of Medical Science (BL2014042), Suzhou Clinical
Key Disease Diagnosis and Treatment Technology Foundation
(LCZX201304), the Plans for Graduate Research and Innovation in
Colleges and Universities of Jiangsu Province, China
(KYZZ15_0334) and Suzhou Medical Key Discipline Project, the
Priority Academic Program Development of Jiangsu Higher Education
Institutions, China (PAPD) and Suzhou Clinical Research Center
of Neurological Disease (Szzx201503).
第一作者机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[2]Institutes of Neuroscience, Soochow University, Suzhou 215123, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[2]Institutes of Neuroscience, Soochow University, Suzhou 215123, China
推荐引用方式(GB/T 7714)：
Li Siyue,Wang Yali,Wang Fen,et al.A New Perspective for Parkinson's Disease: Circadian Rhythm[J].NEUROSCIENCE BULLETIN.2017,33(1):62-72.doi:10.1007/s12264-016-0089-7.
APA：
Li, Siyue,Wang, Yali,Wang, Fen,Hu, Li-Fang&Liu, Chun-Feng.(2017).A New Perspective for Parkinson's Disease: Circadian Rhythm.NEUROSCIENCE BULLETIN,33,(1)
MLA：
Li, Siyue,et al."A New Perspective for Parkinson's Disease: Circadian Rhythm".NEUROSCIENCE BULLETIN 33..1(2017):62-72
