机构：[a]Translational Medicine Research Center, Shanxi Medical University, Taiyuan 030001, Shanxi, China[b]Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China[c]Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China
FOXK2, which belongs to the fork head DNA binding protein family, has been shown to play a critical role in tumorigenesis. Here, we detected FOXK2 expression and its clinical significance in colorectal cancer, which has not been fully investigated before. Results from public database and our cohort indicated that FOXK2 was transcriptionally activated in colorectal cancer tissues compared to non-cancer tissues. High expression of FOXK2 was significantly correlated with poor survival. In vitro cell experiments suggested that FOXK2 promoted cell proliferation. Furthermore, we found that oncogene SOX9 was responsible for the up-regulation of FOXK2 by directly binding on its promoter. Depletion of FOXK2 attenuated SOX9 induced cell growth. In addition, we observed that the expression of FOXK2 was significantly associated with the expression of SOX9 both in the public database and our colorectal cancer tissues. The patients with SOX9(+)FOXK2(+) had a poor overall survival (p = 0.0084). In conclusion, our data suggested that SOX9 transcriptionally activated FOXK2 was involved in the pathogenesis of colorectal cancer and might be a novel target for colorectal cancer therapy. (C) 2016 Elsevier Inc. All rights reserved.
第一作者机构：[a]Translational Medicine Research Center, Shanxi Medical University, Taiyuan 030001, Shanxi, China[*1]Translational Medicine Research Center, Shanxi Medical University, No. 56 South Xinjian Street, Taiyuan 030001, Shanxi, China.
通讯作者：
通讯机构：[*1]Translational Medicine Research Center, Shanxi Medical University, No. 56 South Xinjian Street, Taiyuan 030001, Shanxi, China.
推荐引用方式(GB/T 7714)：
Yu Qian,Suhua Xia,Zhenyu Feng.Sox9 mediated transcriptional activation of FOXK2 is critical for colorectal cancer cells proliferation[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2017,483(1):475-481.doi:10.1016/j.bbrc.2016.12.119.
APA：
Yu Qian,Suhua Xia&Zhenyu Feng.(2017).Sox9 mediated transcriptional activation of FOXK2 is critical for colorectal cancer cells proliferation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,483,(1)
MLA：
Yu Qian,et al."Sox9 mediated transcriptional activation of FOXK2 is critical for colorectal cancer cells proliferation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 483..1(2017):475-481
