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miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts

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机构: [1]Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China [2]Department of General Surgery, The First People’s Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Suzhou 215400, China [3]School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China [4]Oncology Department, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
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关键词: miR-31 colorectal cancer CAFs autophagy biological behaviors

摘要:
Autophagy is a double-edged sword in tumor development. Recent studies have found that miRNAs have an inhibitory effect on the regulation of autophagy. It has been reported that miR-31 plays an important role in the development of colorectal cancer. However, what role miR-31 plays in colorectal cancer-associated fibroblasts (CAFs) has not been determined. In this study, we confirmed that the expression of miR-31 in CAFs was higher than in normal colorectal fibroblasts (NFs). We also found that treatment of CAFs with miR-31 mimic inhibited the expression of the autophagy-related genes Beclin-1, ATG, DRAM and LC3. In addition, we found up-regulation of miR-31 significantly affected colorectal cancer cell behaviors, including proliferation, invasion and apoptosis. Also, up-regulation of miR-31 in CAF could increase the radiosensitivity of colorectal cancer cells co-cultured with CAF. In summary, miR-31 can inhibit autophagy in colorectal CAFs, affect colorectal cancer development, and increase the radiosensitivity of colorectal cancer cells co-cultured with CAF. We hypothesize that miR-31 may become a new target of treatments for colorectal cancer.

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出版当年[2015]版:
大类 | 1 区 医学
小类 | 2 区 肿瘤学 3 区 细胞生物学
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Q1 ONCOLOGY Q1 CELL BIOLOGY
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第一作者机构: [1]Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
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通讯机构: [1]Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China [3]School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China
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