机构：[1]Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Jiangsu, Suzhou, China,[2]Department of Translational Medicine R&D Center, Shenzhen Institute of Advanced Technology, CAS, Guangdong, Shenzhen, China,[3]Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Jiangsu, Suzhou, China,[4]Department of Radiotherapy and Oncology, The Second Clinical Medical College of Jinan University, Shenzhen, China
Low-dose irradiation (LDI) exhibits a positive effect on osteoblasts and inhibitory effect of inflammation. Here, we test the hypothesis that LDI can promote osseointegration and inhibit the inflammatory membrane formation in the presence of titanium (Ti) particles. Endotoxin-free titanium particles were injected into rabbit, prior to the insertion of a Ti6-Al-4-V sticks pre-coated with hydroxyapatite. Two days after operation, both distal femurs of the animal were exposed to 0.5Gy X-ray irradiation. All animals were euthanized 8 weeks after the operation. The PINP concentration was determined at day 0, 2, 4, and 8 weeks after operation. Trabecular morphology around the implants 8 weeks after operation was assessed using micro-CT, then the maximum push out force of simples was assessed using biomechanics test. Five samples in each group were chosen for bone histomorphology study without decalcification 8 weeks after operation. The results confirmed that the LDI can significantly improve ingrowth of bone into the prosthetic interface and stability of the prosthesis when there was no wear particles. Although promotion effects for bone formation induced by LDI can be counteracted by wear particles, LDI can significantly inhibit the interface membrane formation around the implant induced by wear particles. Based on these results, we conclude that LDI may be useful for enhancing the stability of prosthesis when there are no wear particles and for inhibiting the interface membrane formation during the early stage of aseptic loosening in the presence of wear particles. (c) 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1688-1696, 2016.
基金：
Grant sponsor: National Natural Science Foundation of China;
Grant numbers: 81171730, 81171712, 81472105; Grant sponsor:
Shenzhen Peacock Program; Grant number: 110811003586331;
Grant sponsor: Shenzhen Basic Research Program; Grant
numbers: JCYJ20130401170306839, JCYJ20150401150223631;
Grant sponsor: Second Affiliated Hospital of Soochow University
Preponderant Clinic Discipline Group Project; Grant number:
XKQ2015003; Grant sponsor: Suzhou Science and Technology
Development Project; Grant number: SYSD2015084; Grant
sponsor: Jiangsu Provincial Special Program of Clinical Medical
Science; Grant numbers: BL2014040, BL2012004; Grant sponsor:
Guangdong public research and capacity building special grant;
Grant number: 2015A020212030.
第一作者机构：[1]Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Jiangsu, Suzhou, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Jiangsu, Suzhou, China,[2]Department of Translational Medicine R&D Center, Shenzhen Institute of Advanced Technology, CAS, Guangdong, Shenzhen, China,
推荐引用方式(GB/T 7714)：
She Chang,Shi Gao-Long,Xu Wei,et al.Effect of low-dose X-ray irradiation and Ti particles on the osseointegration of prosthetic[J].JOURNAL OF ORTHOPAEDIC RESEARCH.2016,34(10):1688-1696.doi:10.1002/jor.23179.
APA：
She, Chang,Shi, Gao-Long,Xu, Wei,Zhou, Xiao-Zhong,Li, Jian...&Ren, Pei-Gen.(2016).Effect of low-dose X-ray irradiation and Ti particles on the osseointegration of prosthetic.JOURNAL OF ORTHOPAEDIC RESEARCH,34,(10)
MLA：
She, Chang,et al."Effect of low-dose X-ray irradiation and Ti particles on the osseointegration of prosthetic".JOURNAL OF ORTHOPAEDIC RESEARCH 34..10(2016):1688-1696
