机构：[1]Department of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 E Zhongshan Rd, Nanjing 210002, Jiangsu Province, China.[2]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China.[3]Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.[4]Department of Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.[5]Department of Neurology, PLA 123 Hospital, 1052 Yanshan Road, Yuhui District, Bengbu 233000, China.
Background: The neutrophil to lymphocyte ratio (NLR) has been shown to predict short-and long-term outcomes in ischemic stroke patients. We sought to explore the temporal profile of the plasma NLR in stroke patients treated with intravenous thrombolysis (IVT) and its relationship with intracranial bleeding complications after thrombolysis. Methods: A total of 189 ischemic stroke patients were prospectively enrolled. Blood samples for leukocyte, neutrophil, and lymphocyte counts were obtained at admission and at 3-6, 12-18, and 36-48 h after IVT. Head CT was performed on admission and repeated after 36-48 h, and a CT scan was done immediately in case of clinical worsening. Hemorrhagic events were categorized as symptomatic intracranial hemorrhage (sICH) and parenchymal hematomas (PH) according to previously published criteria. Results: An increasing trend in the NLR was observed after stroke, and the NLR was higher in patients who developed PH or sICH at 3-6, 12-18, and 36-48 h after IVT (P < 0.01) than in those without PH or sICH. The optimal cutoff value for the serum NLR as an indicator for auxiliary diagnosis of PH and sICH was 10.59 at 12-18 h. Furthermore, the NLR obtained at 12-18-h post-treatment was independently associated with PH (adjusted odds ratio [OR] 1.14) and sICH (adjusted OR 1.14). In addition, patients with a NLR >= 10.59 had an 8.50-fold greater risk for PH (95 % confidence interval [CI] 2.69-26.89) and a 7.93-fold greater risk for sICH (95 % CI 2.25-27.99) than patients with a NLR < 10.59. Conclusions: NLR is a dynamic variable, and its variation is associated with HT after thrombolysis in stroke patients.
基金：
This study was supported in part by the National Natural Science Foundation
of China (Nos. 81171099, 81501193, and 81471182). The collection of this
study was supported in part by the National Natural Science Foundation of
China (Nos. 81171099, 81501193, and 81471182). The design of the study
and analysis and interpretation of data and writing the manuscript was
supported by the National Natural Science Foundation of China (Nos.
81171099 and 81501193).
第一作者机构：[1]Department of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 E Zhongshan Rd, Nanjing 210002, Jiangsu Province, China.[2]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 E Zhongshan Rd, Nanjing 210002, Jiangsu Province, China.
推荐引用方式(GB/T 7714)：
Zhiliang Guo,Shuhong Yu,Lulu Xiao,et al.Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke[J].JOURNAL OF NEUROINFLAMMATION.2016,13(1):199.doi:10.1186/s12974-016-0680-x.
APA：
Zhiliang Guo,Shuhong Yu,Lulu Xiao,Xin Chen,Ruidong Ye...&Xinfeng Liu.(2016).Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke.JOURNAL OF NEUROINFLAMMATION,13,(1)
MLA：
Zhiliang Guo,et al."Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke".JOURNAL OF NEUROINFLAMMATION 13..1(2016):199
医学