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Quercetin blocks t-AUCB-induced autophagy by Hsp27 and Atg7 inhibition in glioblastoma cells in vitro

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收录情况： ◇ SCIE

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机构： [1]Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China [2]Department of Neurosurgery, Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, China

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关键词： Quercetin Soluble epoxide hydrolase inhibitor Autophagy Heat shock protein 27 Glioma

摘要：

We previously demonstrated that the acquired resistance because of Hsp27 activation weakens the cytotoxic effect of t-AUCB on glioblastoma cells. Since autophagy is regarded as a survival mechanism for cells exposed to cytotoxic agents, the aim of this study is to investigate whether t-AUCB induces autophagy and whether Hsp27 and autophagy are interacted with each other. Our data demonstrated that t-AUCB induces autophagy in glioblastoma cells and regulates multiple autophagy related-gene expression. t-AUCB induces overexpression of Atg7, which is downstream of Hsp27 and participates in the resistance of glioblastoma cells to t-AUCB treatment. Hsp27 inhibitor quercetin suppresses Atg7 expression and strengthens t-AUCB-induced cell death by autophagy blockage. We concluded that combination of quercetin and t-AUCB might be a potential strategy for glioblastoma treatment.

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出版当年[2015]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区临床神经病学 3 区肿瘤学

JCR分区：

出版当年[2014]版：

Q2 CLINICAL NEUROLOGY Q2 ONCOLOGY

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q2 ONCOLOGY

影响因子： 3.2 最新[2023版] 3.7 最新五年平均 3.07 出版当年[2014版] 3.104 出版当年五年平均 2.787 出版前一年[2013版] 2.754 出版后一年[2015版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China

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通讯作者：

通讯机构： [1]Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China [2]Department of Neurosurgery, Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, China

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