机构：[1]Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China[2]Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
Purpose betatrophin has been reported to boost beta cell expansion in insulin resistant states. Pregnancy is a well-recognized physiological state of insulin resistance. Betatrophin levels in pregnant women and their relationships with metabolic variables remain to be elucidated. Methods A total of 49 pregnant women and 31 age-matched unpregnant women with normal glucose regulation (UP-NGR) were included. Among these subjects, according to results from 75 g oral glucose tolerance test (OGTT), 22 women were diagnosed as having gestational diabetes mellitus (GDM). Results Our study found that pregnant women, regardless of their glucose regulation status, had remarkably higher triglycerides (TG), total cholesterol (TC), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of beta-cell function (HOMA-beta). However, GDM patients had much lower HOMA-beta compared with those of pregnant women with normal glucose regulation (P-NGR). Participants of the P-NGR group had almost 4 times higher levels of betatrophin than those of the UP-NGR group. Although betatrophin levels were lower in the GDM group than those of the P-NGR group, the difference did not reach statistical significance. Spearman correlation analysis showed that betatrophin levels were positively and significantly associated with total cholesterol, triglycerides, highdensity lipoprotein cholesterol (HDL-c), FINS and HOMA-beta. However, adjustments of TC, TG and HDL-c eliminated the association between HOMA-beta and betatrophin. Conclusions Pregnant women have significantly higher betatrophin levels in comparison to unpregnant women. Betatrophin levels are positively and significantly associated with beta cell function and lipid levels. Furthermore, lipids may contribute to the association between betatrophin and beta cell function.
基金：
The work is supported by the
grants from the National Natural Science Foundation of
China (No. 81502865), the Natural Science Foundation of
Jiangsu Province (No. SBK201340560), and the Natural
Science Foundation for Colleges and Universities in
Jiangsu Province (No. 13KJB320017).
语种：
外文
WOS：
PubmedID：
第一作者：
第一作者机构：[1]Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Endocrinology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China
推荐引用方式(GB/T 7714)：
Yun Huang,Chen Fang,Zhimin Ma,et al.Betatrophin Levels were Increased in Pregnant Women with or without Gestational Diabetes Mellitus and Associated with Beta Cell Function[J].REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA.2016,38(6):287-92.doi:10.1055/s-0036-1584566.
APA：
Yun Huang,Chen Fang,Zhimin Ma,Heming Guo,Ruihua Wang&Ji Hu.(2016).Betatrophin Levels were Increased in Pregnant Women with or without Gestational Diabetes Mellitus and Associated with Beta Cell Function.REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA,38,(6)
MLA：
Yun Huang,et al."Betatrophin Levels were Increased in Pregnant Women with or without Gestational Diabetes Mellitus and Associated with Beta Cell Function".REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA 38..6(2016):287-92
