机构：[1]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Neurology, Suzhou Hospital of Traditional Chinese Medicine, Suzhou, China[3]Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China[4]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases & Institute of Neuroscience, Soochow University, Suzhou, China.
Background: We investigated whether admission serum calcium and phosphate levels are associated with short-and long-term outcomes in patients with acute intracerebral hemorrhage. Methods: A total of 365 patients with acute intracerebral hemorrhage were enrolled in this study. Participants were classified into 4 subgroups according to serum calcium or phosphate quartiles. Demographic characteristics, lifestyle risk factors, medical history, and other clinical characteristics were recorded for all the participants. Excellent outcome was defined as discharge or 3-month modified Rankin scale scores of 0-1. Results: Univariate analysis comparing the highest and lowest quartiles indicated that an elevated calcium level was associated with 2.26- and 2.28-fold increases in the odds for discharge and 3-month excellent outcome, respectively. After adjustment for age, sex, and other potential risk factors, patients in the highest quartile still had significantly increased odds of discharge and 3-month excellent outcome; the corresponding odds ratios (ORs) were 3.43 (95% confidence interval [[CI], 1.03-11.44) and 5.36 (95% CI, 1.69-16.98). When calcium was divided into two groups, the ORs of higher calcium were 2.9 (95% CI, 1.1-7.62) and 2.8 (95% CI, 1.15-6.82) for discharge and 3-month excellent outcome, respectively. However, no significant association was observed between serum phosphate and excellent outcome. Conclusions: Elevated admission serum calcium level but not phosphate level is positively associated with excellent outcome at discharge or 3 months in acute intracerebral hemorrhage patients.
基金：
This work was supported in part by grants from the National Natural Science Foundation of China (81471195, 81200894), the Science and
Education Methodist Youth Science and Technology Project of Suzhou Health Bureau (KJXW2011010), and the Second Affiliated Hospital of
Soochow University Preponderant Clinic Discipline Group Project Funding (XKQ2015002).
第一作者机构：[1]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.[*2]Department of Neurology, Second Affiliated Hospital of Soochow University, No.1055, Sanxiang Road, Suzhou, Jiangsu 215004, China.
推荐引用方式(GB/T 7714)：
Shoujiang You ,Qiao Han ,Jiaping Xu ,et al.Serum Calcium and Phosphate Levels and Short- and Long-Term Outcomes in Acute Intracerebral Hemorrhage Patients[J].JOURNAL OF STROKE & CEREBROVASCULAR DISEASES.2016,25(4):914-20.doi:10.1016/j.jstrokecerebrovasdis.2015.12.023.
APA：
Shoujiang You,,Qiao Han,,Jiaping Xu,,Chongke Zhong,,Yu Zhang,...&Yongjun Cao,.(2016).Serum Calcium and Phosphate Levels and Short- and Long-Term Outcomes in Acute Intracerebral Hemorrhage Patients.JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,25,(4)
MLA：
Shoujiang You,,et al."Serum Calcium and Phosphate Levels and Short- and Long-Term Outcomes in Acute Intracerebral Hemorrhage Patients".JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 25..4(2016):914-20
