机构：[1]Children’s Hospital of Shanxi Province, Taiyuan, Shanxi Province, China[2]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province, China
Up to now, over 1,000 experimental treatments found in cells and rodents have been difficult to translate to human ischemic stroke. Since ischemia and reperfusion, two separate stages of ischemic stroke, have different pathophysiological mechanisms leading to brain injury, a combination of protective agents targeting ischemia and reperfusion respectively may obtain substantially better results than a single agent. Normobaric hyperoxia (NBO) has been shown to exhibit neuro-and vaso-protective effects by improving tissue oxygenation when it is given during ischemia, however the effect of NBO would diminish when the duration of ischemia and reperfusion was extended. Therefore, during reperfusion drug treatment targeting inflammation, oxidative stress and free radical scavenger would be a useful adjuvant to extend the therapeutic window of tissue plasminogen activator, the only United States Food and Drug Administration (FDA) approved treatment for acute ischemic stroke. In this review, we discussed the neuro-and vaso-protective effects of NBO and recent finding of combining NBO with other drugs.
基金：
This work was supported by Soochow University Research
starting funds to XJ (Q 421500113), the Priority Academic
Program Development of Jiangsu Higher Education Institutions
of China.
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
无
最新[2025]版：
大类|3 区医学
小类|3 区医学：研究与实验
第一作者：
第一作者机构：[1]Children’s Hospital of Shanxi Province, Taiyuan, Shanxi Province, China
共同第一作者：
通讯作者：
通讯机构：[2]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province, China
推荐引用方式(GB/T 7714)：
Li-jun Liang,Jin-ming Yang,Xin-chun Jin.Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?[J].MEDICAL GAS RESEARCH.2016,6(1):33-38.doi:10.4103/2045-9912.179343.
APA：
Li-jun Liang,Jin-ming Yang&Xin-chun Jin.(2016).Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?.MEDICAL GAS RESEARCH,6,(1)
MLA：
Li-jun Liang,et al."Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?".MEDICAL GAS RESEARCH 6..1(2016):33-38
