机构：[1]Department of Urology, Guangdong No. 2 Provincial People’s Hospital, Guangzhou, China[2]George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA[3]Department of Urology, the Second Affiliated Hospital of Soochow University, Suzhou, China[4]Chawnshang Chang Liver Cancer Center, Department of Urology, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China[5]Sex Hormone Research Center, China Medical University/Hospital, Taichung, Taiwan
Testicular nuclear receptor 4 (TR4), a member of the nuclear receptor superfamily, may play important roles to modulate the metabolic diseases and prostate tumorigenesis. Here we found TR4 could increase prostate cancer (PCa) cell invasion. Mechanism dissection revealed that TR4 might increase PCa cell invasion via decreasing the miR-373-3p expression that resulted in the activation of the TGF beta R2/p-Smad3 signals. The in vivo mouse model using orthotopically xenografted CWR22Rv1 cell line transfected with luciferase-reporter confirmed in vitro cell line studies showing TR4 increased PCa metastasis via decreasing the miR-373-3p expression. Together, these data suggest that TR4 may increase PCa metastasis via a newly identified signal and targeting these TR4/miR-473-3p/TGF beta R2/p-Smad3 signals using TR4 antagonist or TR4-siRNA or miR-373-3p may allow us to develop a new potential therapeutic approach to better suppress PCa metastasis.
基金：
This study was supported by NIH grants (CA122840 and CA156700), George Whipple Professorship Endowment, the Taiwan Department of Health Clinical Trial Research Center of Excellence (DOH99- TD-B-111-004 to China Medical University, Taichung, Taiwan). National Natural Science Foundation of China (Grant No. 81472776) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
第一作者机构：[1]Department of Urology, Guangdong No. 2 Provincial People’s Hospital, Guangzhou, China[2]George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
共同第一作者：
通讯作者：
通讯机构：[1]Department of Urology, Guangdong No. 2 Provincial People’s Hospital, Guangzhou, China[2]George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA[5]Sex Hormone Research Center, China Medical University/Hospital, Taichung, Taiwan
推荐引用方式(GB/T 7714)：
Xiaofu Qiu,Jin Zhu,Yin Sun,et al.TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGF beta R2/p-Smad3 signals[J].ONCOTARGET.2015,6(17):15397-409.doi:10.18632/oncotarget.3778.
APA：
Xiaofu Qiu,Jin Zhu,Yin Sun,Kun Fan,Dong-Rong Yang...&Chawnshang Chang.(2015).TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGF beta R2/p-Smad3 signals.ONCOTARGET,6,(17)
MLA：
Xiaofu Qiu,et al."TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGF beta R2/p-Smad3 signals".ONCOTARGET 6..17(2015):15397-409
