机构：[1]Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China[2]Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Objective To compare the antepartum and postpartum plasma concentrations of endothelial microparticles (EMPs) in patients with pre-eclampsia with those of healthy control subjects with normal pregnancies. Methods Plasma concentrations of EMPs were measured using specific antibody labelling and flow cytometry prior to delivery by caesarean section (antepartum), and again at 24h and 72h postpartum. The correlations between EMP concentration and mean arterial pressure (MAP), and between EMP concentration and 24-h urine protein were analysed. Results A total of 59 patients with pre-eclampsia and 60 healthy control subjects participated in the study. The antepartum plasma EMP concentration was significantly higher in patients with pre-eclampsia than in healthy control subjects with normal pregnancies (2863.51543.1 versus 1703.0 +/- 592.2EMPs/ml, respectively); similar findings were observed at 24h postpartum (1836.7 +/- 1153.8 versus 1421.8 +/- 760.2EMPs/ml, respectively). There was no significant difference between the two groups at 72h postpartum. The antepartum plasma EMP concentration in patients with pre-eclampsia demonstrated a significant positive correlation with MAP (r=0.716) and with 24-h urine protein (r=0.770). Conclusion Plasma EMP concentration might serve as a biomarker to evaluate the severity of pre-eclampsia in the future.
基金：
The study received financial support from the
Postdoctoral Research Fund of Jiangsu Province
(no. 0901053C), which was provided by the
Science and Technology Department of Jiangsu
Province.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2013]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2012]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou 215004, Jiangsu Province, China.
推荐引用方式(GB/T 7714)：
Li Ling,Huaping Huang,Lingyun Zhu,et al.Evaluation of plasma endothelial microparticles in pre-eclampsia[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2014,42(1):42-51.doi:10.1177/0300060513504362.
APA：
Li Ling,Huaping Huang,Lingyun Zhu,Ting Mao,Qian Shen&Hong Zhang.(2014).Evaluation of plasma endothelial microparticles in pre-eclampsia.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,42,(1)
MLA：
Li Ling,et al."Evaluation of plasma endothelial microparticles in pre-eclampsia".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 42..1(2014):42-51
