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The NF-kappa B pathway: regulation of the instability of atherosclerotic plaques activated by Fg, Fb, and FDPs

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收录情况： ◇ SCIE

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机构： [1]Department of Neurology, The Second Affiliated Hospital of Soochow University, No. 1055, Sanxiang Road, Suzhou 215004, Jiangsu, People’s Republic of China [2]Institute of Neuroscience, Soochow University, Suzhou 215123, People’s Republic of China

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关键词： Fibrin(ogen) Fibrinogen degradation products Atherosclerosis Matrix metalloproteinase Vascular endothelial growth factor Nuclear factor-kappa B

摘要：

Recently, the molecular mechanism responsible for the instability of atherosclerotic plaques has gradually become a hot topic among researchers and clinicians. Matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) play an important role in the processes of formation and development of atherosclerosis. In this study, we established and employed the transwell co-culture system of rabbit aortic endothelial cells and smooth muscle cells to explore the relationship between fibrin (Fb), fibrinogen (Fg), and/or their degradation products (FDPs) in relation to the instability of atherosclerotic plaques; meanwhile, we observed the effects of Fg, Fb, and FDPs on the mRNA levels of MMPs and VEGF as well as on the activation of nuclear factor-kappa B (NF-kappa B). We concluded that Fb, Fg, and FDPs are involved in the progression of the instability of atherosclerotic plaques via increasing the expression of MMPs and VEGF. This effect might be mediated by the NF-(DB)-B-0 pathway.

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出版当年[2012]版：

大类 | 4 区生物

小类 | 4 区细胞生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 3 区细胞生物学

JCR分区：

出版当年[2011]版：

Q3 CELL BIOLOGY

最新[2023]版：

Q3 CELL BIOLOGY

影响因子： 3.5 最新[2023版] 3.3 最新五年平均 2.057 出版当年[2011版] 1.988 出版当年五年平均 2.168 出版前一年[2010版] 2.329 出版后一年[2012版]

第一作者：

第一作者机构： [1]Department of Neurology, The Second Affiliated Hospital of Soochow University, No. 1055, Sanxiang Road, Suzhou 215004, Jiangsu, People’s Republic of China [2]Institute of Neuroscience, Soochow University, Suzhou 215123, People’s Republic of China

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通讯作者：

通讯机构： [1]Department of Neurology, The Second Affiliated Hospital of Soochow University, No. 1055, Sanxiang Road, Suzhou 215004, Jiangsu, People’s Republic of China

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