机构：[1]Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004[2]School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, P.R. China
microRNAs (miRNAs) are a group of small non-coding RNAs that are similar to 22 (18 to 25) nucleotides (nt) long and have been associated with a variety of diseases, including cancer. Increasing evidence indicates that miRNAs are essential in the development, diagnosis, treatment and prognosis of a variety of tumors. The utility of miRNAs as biomarkers for diagnosis and of target molecules for the treatment of cancers is increasingly being recognized. With the discovery of circulating miRNAs, a non-invasive approach for the diagnosis and treatment of cancer has been identified. This review summarizes the role of miRNAs in the development of different tumors, as well as a variety of other biological events. Moreover, this review focuses on analyzing the function and mechanism of gastric cancer-related miRNAs and investigates the importance of circulating miRNAs in gastric cancer, as well as their origin. Finally, this review lists a number of the problems that must be solved prior to miRNAs being used as reliable non-invasive tools for the diagnosis, treatment and prognosis of gastric cancer.
基金：
The present study was partially supported by the National Natural Science Foundation of China (81172348, 81102078), the Jiangsu Province Health Department Research Project (H201313) and the Suzhou Social Development Fund Project (200823).
第一作者机构：[1]Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004
共同第一作者：
通讯作者：
通讯机构：[*1]Department of General Surgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxian Road, Suzhou 215004, P.R. China[*2]School of Radiation Medicine and Public Health, Medical College of Soochow University, No. 199 Renai Road, Suzhou 215123, P.R. China
推荐引用方式(GB/T 7714)：
XIAOHUI XU,XIAODONG YANG,CHUNGEN XING,et al.miRNA: The nemesis of gastric cancer[J].ONCOLOGY LETTERS.2013,6(3):631-641.doi:10.3892/ol.2013.1428.
APA：
XIAOHUI XU,XIAODONG YANG,CHUNGEN XING,SHUYU ZHANG&JIANPING CAO.(2013).miRNA: The nemesis of gastric cancer.ONCOLOGY LETTERS,6,(3)
MLA：
XIAOHUI XU,et al."miRNA: The nemesis of gastric cancer".ONCOLOGY LETTERS 6..3(2013):631-641
