机构：[1]Clinical Molecular Diagnostic Center, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China[2]SNP Institute, University of South China, Henyang 421001, China[3]Department of Pharmacology, University of Sherbrooke, Sherbrooke, QC J1H5N4, Canada[4]Beckman Research Institute, City of Hope, Duarte, CA 91010, USA[5]Department of Pharmacology, Medical College, Soochow University, Suzhou 215123, China
Indels in evolutionary studies are rapidly decayed obeying a power law. The present study analyzed the length distribution of small insertions and deletions associated with human diseases and confirmed that the decay pattern of these small mutations is similar to that of indels when the mutation datasets are large enough. The describable decay pattern of somatic mutations may have application in the evaluation of varied penetrance of different mutations and in association study of gene mutation with carcinogenesis.
基金：
Department of Personnel Jiangsu province “Liu Da Ren Cai Gao Feng” grant (07-B-033), and The
National Natural Science Foundation of China (No. 30970877).
第一作者机构：[1]Clinical Molecular Diagnostic Center, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China
通讯作者：
通讯机构：[5]Department of Pharmacology, Medical College, Soochow University, Suzhou 215123, China
推荐引用方式(GB/T 7714)：
Jia Zhang,Li Xiao,Yufang Yin,et al.A Law of Mutation: Power Decay of Small Insertions and Small Deletions Associated with Human Diseases[J].APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY.2010,162(2):321-8.doi:10.1007/s12010-009-8793-7.
APA：
Jia Zhang,Li Xiao,Yufang Yin,Pierre Sirois,Hanlin Gao&Kai Li.(2010).A Law of Mutation: Power Decay of Small Insertions and Small Deletions Associated with Human Diseases.APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,162,(2)
MLA：
Jia Zhang,et al."A Law of Mutation: Power Decay of Small Insertions and Small Deletions Associated with Human Diseases".APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 162..2(2010):321-8
