机构：[1]The Second Affiliated Hospital of Soochow University,[2]The First Affiliated Hospital of Soochow University,[3]School of Radiology and Public Health, Soochow University, Suzhou, Jiangsu, China
Materials and methods: BMC were irradiated in vitro at various low-dose X-rays radiation. Tritiated thymidine (<SU3</SUH-TdR) incorporation was adopted to measure the proliferation of the BMC in vitro, and then the optimal radiation doses were selected for further study in vivo. Irradiated recipient mice (7.5 Gy) were infused by BMC exposed to 6 and 8 cGy. The counts of recipients' peripheral blood cells (PBC) and bone marrow mononuclear cells (BMMNC) were monitored at the 5th, 10th, 15th, and 30th day after BMC infusion. The colony-forming units in the recipient spleens (CFU-S) were calculated at the 10th day after infusion. Results: Exposed to 6 and 8 cGy, BMC demonstrated significant proliferative activities in vitro. When the recipient mice receiving BMC pre-exposed to low dose radiation (6 and 8 cGy), the counts of white blood cell (WBC), BMMNC and CFU-S were consistently higher than those in control. Conclusions: BMC of donor irradiated by LDR in vitro may facilitate the hematopoietic reconstitution of the recipient mice.
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外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2009]版：
大类|4 区医学
小类|1 区核科学技术4 区生物学4 区核医学
最新[2023]版：
大类|4 区医学
小类|3 区生物学3 区核科学技术4 区核医学
JCR分区：
出版当年[2008]版：
Q1NUCLEAR SCIENCE & TECHNOLOGYQ2BIOLOGYQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1NUCLEAR SCIENCE & TECHNOLOGYQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2BIOLOGY
