机构:[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China神经内科首都医科大学宣武医院[2]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China放射科首都医科大学宣武医院
Paraneoplastic myelopathy is rare paraneoplastic neurological syndromes. We reviewed patients through medical records system and screened patients who presented with myelopathy, and/or coexisting cancer, and/or onconeural antibodies. Nine patients were identified as paraneoplastic myelopathy presenting with progressive subacute (2/9) or insidious (7/9) myelopathy. CSF abnormalities included elevated protein, 5; pleocytosis, 4; excess oligoclonal bands, 6. Seven patients had onconeural antibody. Cancer was confirmed histopathologically in 6 and diagnosed by PET-CT in 1. Four patients had symmetric, longitudinally extensive grey matter or tract-specific changes on spinal cord MRI. It was associated with significant morbidity and had poor response to treatment.
基金:
National Key R&D Program of China, Precision Medicine Program, Cohort study on nervous system diseases [2017YFC0907700]; National Science Foundation of China [81571633]; Beijing health System Clinicians Training Plan [20143054]
第一作者机构:[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China
通讯作者:
通讯机构:[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China
推荐引用方式(GB/T 7714):
Liu Zheng,Jiao Lidong,Qiu Zhandong,et al.Clinical characteristics of patients with paraneoplastic myelopathy[J].JOURNAL OF NEUROIMMUNOLOGY.2019,330:136-142.doi:10.1016/j.jneuroim.2019.03.001.
APA:
Liu, Zheng,Jiao, Lidong,Qiu, Zhandong,Da, Yuwei,Tang, Yi...&Dong, Huiqing.(2019).Clinical characteristics of patients with paraneoplastic myelopathy.JOURNAL OF NEUROIMMUNOLOGY,330,
MLA:
Liu, Zheng,et al."Clinical characteristics of patients with paraneoplastic myelopathy".JOURNAL OF NEUROIMMUNOLOGY 330.(2019):136-142