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Clinical characteristics of patients with paraneoplastic myelopathy

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机构: [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China [2]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China
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关键词: Paraneoplastic Myelopathy Autoimmune Spinal cord

摘要:
Paraneoplastic myelopathy is rare paraneoplastic neurological syndromes. We reviewed patients through medical records system and screened patients who presented with myelopathy, and/or coexisting cancer, and/or onconeural antibodies. Nine patients were identified as paraneoplastic myelopathy presenting with progressive subacute (2/9) or insidious (7/9) myelopathy. CSF abnormalities included elevated protein, 5; pleocytosis, 4; excess oligoclonal bands, 6. Seven patients had onconeural antibody. Cancer was confirmed histopathologically in 6 and diagnosed by PET-CT in 1. Four patients had symmetric, longitudinally extensive grey matter or tract-specific changes on spinal cord MRI. It was associated with significant morbidity and had poor response to treatment.

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基金编号: 2017YFC0907700 81571633 20143054

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出版当年[2018]版:
大类 | 3 区 医学
小类 | 4 区 免疫学 4 区 神经科学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 免疫学 4 区 神经科学
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出版当年[2017]版:
Q3 IMMUNOLOGY Q3 NEUROSCIENCES
最新[2023]版:
Q2 NEUROSCIENCES Q3 IMMUNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

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第一作者机构: [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China
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通讯机构: [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China
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