机构：[1]Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA[2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China神经外科[3]Department of Orthopedics, Hong Hui Hospital, Affiliated Hospital of the Medical School, Xi’an Jiaotong University, Xi’an 710004, China[4]Department of Neurobiology, Capital Medical University, Beijing 100069, China[5]Department of Orthopedics, Luhe Hospital, Capital Medical University, Beijing 100020, China[6]Department of Neurological Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury (SCI). Currently, however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation (SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations, classification, potential underlying etiology, and current challenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed.
第一作者机构：[1]Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
通讯作者：
通讯机构：[1]Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA[6]Department of Neurological Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
推荐引用方式(GB/T 7714)：
Qian Huang,Wanru Duan,Eellan Sivanesan,et al.Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury.[J].Neuroscience bulletin.2019,35(3):527-539.doi:10.1007/s12264-018-0320-9.
APA：
Qian Huang,Wanru Duan,Eellan Sivanesan,Shuguang Liu,Fei Yang...&Yun Guan.(2019).Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury..Neuroscience bulletin,35,(3)
MLA：
Qian Huang,et al."Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury.".Neuroscience bulletin 35..3(2019):527-539
