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Neuroprotective mechanism involved in spinal cord stimulation postconditioning

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机构： [a]Department of Cardiac Surgery, The First Hospital of Tsinghua University, Beijing, China [b]Department of Anesthesiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, China [c]Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China [d]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China

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关键词： spinal cord ischemia/reperfusion injury spinal cord stimulation postconditioning α-bungarotoxin α7 nicotinic acetylcholine receptor

摘要：

Objectives: Delayed paraplegia developed postoperatively after thoracoabdominal aneurysm surgery is primarily associated with spinal cord ischemia/reperfusion injury. Our previous study suggested that spinal cord stimulation postconditioning protected the spinal cord from ischemia/reperfusion injury through microglia inhibition. In this study, we further investigated whether α7 nicotinic acetylcholine receptors were involved in the neuroprotective mechanism of spinal cord stimulation. Methods: Rabbits were randomly assigned to sham, control, 2 Hz, α-bungarotoxin, and 2 Hz-α-bungarotoxin groups (n = 24/group). Transient spinal cord ischemia was performed on all rabbits except rabbits in the sham group. Rabbits in the control group received no further intervention, rabbits in the 2 Hz group were given 2 Hz spinal cord stimulation, rabbits in the α-bungarotoxin group received prescribed intrathecal α-bungarotoxin (α-bungarotoxin, a specific α7 nicotinic acetylcholine receptor antagonist) injections, and rabbits in the 2 Hz-α-bungarotoxin group received both α-bungarotoxin injections and 2 Hz spinal cord stimulation. Hind-limb neurologic function was assessed, and spinal cord histologic examination, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining, and microglia staining were performed at 8 hours, 1 day, 3 days, and 7 days of reperfusion. Results: Rabbits in the 2 Hz group had significantly better neurologic functions, more α-motor neurons, and lower terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling–positive neuron rates and microglia area/anterior horn area ratios (microglia area ratios) than the control group. The neurologic functions of the α-bungarotoxin group were significantly worse than those of the control group, whereas other results were not significantly different from the control group. The results of the 2 Hz-α-bungarotoxin group were insignificant to the control group except for the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling–positive neuron rates, which were significantly lower than in the control group. Conclusions: The neuroprotective effects of spinal cord stimulation postconditioning against spinal cord ischemia/reperfusion injury were partially mediated by activating α7 nicotinic acetylcholine receptors. © 2019

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出版当年[2018]版：

大类 | 2 区医学

小类 | 2 区呼吸系统 2 区外科 3 区心脏和心血管系统

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区外科 2 区心脏和心血管系统 2 区呼吸系统

JCR分区：

出版当年[2017]版：

Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Q1 SURGERY Q1 RESPIRATORY SYSTEM

最新[2023]版：

Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Q1 RESPIRATORY SYSTEM Q1 SURGERY

影响因子： 4.9 最新[2023版] 4.9 最新五年平均 4.88 出版当年[2017版] 4.334 出版当年五年平均 4.446 出版前一年[2016版] 5.261 出版后一年[2018版]

第一作者：

第一作者机构： [a]Department of Cardiac Surgery, The First Hospital of Tsinghua University, Beijing, China

通讯作者：

通讯机构： [b]Department of Anesthesiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, China [c]Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China [d]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China [*1]Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China [*2]Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China [*3]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China

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Neuroprotective mechanism involved in spinal cord stimulation postconditioning

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