Spinal cord stimulation postconditioning reduces microglial activation through down-regulation of ERK1/2 phosphorylation during spinal cord ischemic reperfusion in rabbits
机构：[1]Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China临床科室麻醉中心首都医科大学附属安贞医院
Microglial activation plays a critical role in spinal cord ischemic reperfusion injury. Spinal cord stimulation preconditioning and postconditioning has shown spinal cord protection in ischemic reperfusion injury in animal studies. However, whether spinal cord stimulation could reduce microglial activation is still unclear. In this study, rabbits experienced 28-min infrarenal aorta occlusion and reperfusion for 8h, 1, 3, and 7 days correspondingly. Immediately after reperfusion, rabbits received spinal cord stimulation of 2 or 50Hz for 30 min and daily for a week. The results showed that spinal cord stimulation of 2Hz reduced microglial activation. Microglial activation was accompanied with up-regulated p-ERK1/2, and microglial inhibition by 2Hz spinal cord stimulation was associated with down-regulated p-ERK1/2. Spinal cord stimulation increased the expression of IL-1. Our results revealed, for the first time, that spinal cord stimulation postconditioning suppresses microglial activation during spinal cord ischemic reperfusion by down-regulation of p-ERK1/2, which may be the protective mechanism of spinal cord stimulation.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7152046]; Beijing Major Science and Technology Projects from Beijing Municipal Science and Technology Commission [Z171100001017083]; Special Research Fund for Public Welfare Industry of Health [201402009]
第一作者机构：[1]Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China[*1]Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, 2 Anzhen Road, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Dong Xiuhua,Li Huixian,Lu Jiakai,et al.Spinal cord stimulation postconditioning reduces microglial activation through down-regulation of ERK1/2 phosphorylation during spinal cord ischemic reperfusion in rabbits[J].NEUROREPORT.2018,29(14):1180-1187.doi:10.1097/WNR.0000000000001093.
APA：
Dong, Xiuhua,Li, Huixian,Lu, Jiakai,Yang, Yanwei,Jing, He...&Cheng, Weiping.(2018).Spinal cord stimulation postconditioning reduces microglial activation through down-regulation of ERK1/2 phosphorylation during spinal cord ischemic reperfusion in rabbits.NEUROREPORT,29,(14)
MLA：
Dong, Xiuhua,et al."Spinal cord stimulation postconditioning reduces microglial activation through down-regulation of ERK1/2 phosphorylation during spinal cord ischemic reperfusion in rabbits".NEUROREPORT 29..14(2018):1180-1187
