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Deep Brain Stimulation Improves Motor Function in Rats with Spinal Cord Injury by Increasing Synaptic Plasticity

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收录情况： ◇ SCIE

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机构： [1]Department of Orthopedics, Xuanwu Hospital Capital Medical University, Beijing [2]Beijing Key Laboratory of Mental Disorders & The National Clinical Research Center for Mental Disorder, Beijing Anding Hospital, Capital Medical University, Beijing [3]The fourth Department of Orthopedics, Jincheng General Hospital, Jincheng, Shanxi Province [4]Department of Neurology, Jincheng General Hospital, Jincheng, Shanxi Province, China

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关键词： Brain-derived neurotrophic factor Deep brain stimulation Spinal cord injury Synaptic plasticity

摘要：

Objective: To investigate the effect of deep brain stimulation (DBS) on rats with spinal cord injury (SCI) and its possible molecular mechanism. Methods: A rat SCI model was prepared using a modified Allen method. The animals were randomly divided into 3 groups (n = 12 per group): the sham group, the SCI group, and the SCI + DBS group. Then, DBS was applied to the rats in the SCI + DBS group for half an hour per day for 4 weeks. Basso, Beattie, and Bresnahan scores were used to assess spinal function. Results: DBS significantly improved hindlimb motor function in SCI rats, and the protein expression levels of brain-derived neurotrophic factor, the mammalian target of rapamycin, tropomyosin-related kinase B, protein kinase B, p70 ribosomal S6 protein kinase, postsynaptic density protein 95, and synaptophysin increased correspondingly. Conclusions: DBS improves motor function in rats with SCI by increasing synaptic plasticity via tropomyosin-related kinase B–protein kinase B–mammalian target of rapamycin pathway. © 2020 Elsevier Inc.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 3 区外科 4 区临床神经病学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区外科

JCR分区：

出版当年[2018]版：

Q3 SURGERY Q4 CLINICAL NEUROLOGY

最新[2023]版：

Q2 SURGERY Q3 CLINICAL NEUROLOGY

影响因子： 1.9 最新[2023版] 2 最新五年平均 1.723 出版当年[2018版] 2.135 出版当年五年平均 1.924 出版前一年[2017版] 1.829 出版后一年[2019版]

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第一作者机构： [1]Department of Orthopedics, Xuanwu Hospital Capital Medical University, Beijing [3]The fourth Department of Orthopedics, Jincheng General Hospital, Jincheng, Shanxi Province

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Deep Brain Stimulation Improves Motor Function in Rats with Spinal Cord Injury by Increasing Synaptic Plasticity

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