机构：[a]Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.[b]Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Abstract
Objective: This meta-analysis assessed the long-term efficacy of deep brain stimulation (DBS) of the subthalamic nucleus (STN)
and globus pallidus interna (GPi) for Parkinson disease (PD).
Methods: PubMed, Cochrane Library, and Clinical Trials databases were searched. Outcomes were unified Parkinson disease
rating scale section (UPDRS) III off-medication score, Parkinson’s disease questionnaire: 39 activities of daily living (PDQ-39 ADL)
score, and levodopa-equivalent dosage after DBS.
Results: During the off-medication state, pooled weighted mean difference (WMD) of UPDRS III score was .69 (95% confidence
interval [CI]=1.77 to 3.16, P=.58). In subgroup analysis, WMD of UPDRS III off-medication scores from baseline to 2 years and 3
years post-DBS were .61 (95% CI=2.97 to 1.75, P=.61) and 2.59 (95% CI=2.30 to 7.47, P=.30). PooledWMDof changes in
tremor, rigidity, and gait scores were 1.12 (95% CI=0.05 to 2.28, P=.06), 1.22 (95% CI=0.51 to 2.94, P=.17) and .37 (95%
CI=0.13 to 0.87, P=.15), respectively. After DBS, pooled WMD of PDQ-39 ADL and LED were 3.36 (95% CI=6.36 to 0.36,
P=.03) and 194.89 (95% CI=113.16 to 276.63, P<.001).
Conclusions: STN-DBS and GPi-DBS improve motor function and activities of daily living for PD. Differences in the long-term
efficacy for PD on motor symptoms were not observed.
Abbreviations: BDI = Beck depression inventory, DBS = deep brain stimulation, GPi = globus pallidus interna, IQR = interquartile
range, LED = levodopa-equivalent dosage, PD = Parkinson’s disease, PDQ-39 ADL = Parkinson’s disease questionnaire: 39
activities of daily living, STN = subthalamic nucleus, UPDRS = unified Parkinson’s disease rating scale section, WMD = weighted
mean difference
基金：
This study was supported by the Science and Technology Department
of Sichuan Province [grant numbers 2013SZZ002, LZ-LY-9]; the Health and
Family Planning Commission of Sichuan Province [grant number 16PJ557]; and
the Southwest Medical University [grant number 2013ZRQN068].
第一作者机构：[a]Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
通讯作者：
通讯机构：[*1]Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, 25 Taiping Street, Jiangyang Region, Luzhou 646000, China
推荐引用方式(GB/T 7714)：
Lilei Peng,Jie Fu,Yang Ming,et al.The long-term efficacy of STN vs GPI deep brain stimulation on Gait and Axial Function in Parkinson's Disease Patients[J].MOVEMENT DISORDERS.2019,34:
APA：
Lilei Peng,Jie Fu,Yang Ming,Shan Zeng,Haiping He&Ligang Chen.(2019).The long-term efficacy of STN vs GPI deep brain stimulation on Gait and Axial Function in Parkinson's Disease Patients.MOVEMENT DISORDERS,34,
MLA：
Lilei Peng,et al."The long-term efficacy of STN vs GPI deep brain stimulation on Gait and Axial Function in Parkinson's Disease Patients".MOVEMENT DISORDERS 34.(2019)
医学