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Long non-coding RNA XIST predicts poor prognosis and promotes malignant phenotypes in osteosarcoma

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收录情况： ◇ SCIE

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机构： [1]Department of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China

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关键词： osteosarcoma long non-coding RNA XIST prognosis

摘要：

Increasing evidence indicates that long non-coding RNA (lncRNA) is involved in a number of types of human cancer and functions as an oncogene or tumor suppressor. However, little is known about the role of lncRNA X-inactive specific transcript (XIST) in osteosarcoma. In the present study, the expression of lncRNA XIST was analyzed in 56 osteosarcoma tissues and their corresponding normal bone tissues by reverse transcription-quantitative polymerase chain reaction. Increased lncRNA XIST expression was observed in osteosarcoma tissues compared with the normal tissues and was positively associated with advanced Enneking stage. In addition, lncRNA XIST may be used as an independent risk factor for the overall survival of patients with osteosarcoma. Knockdown of lncRNA XIST inhibited cell proliferation, induced cell apoptosis and arrested the cell cycle. The inhibition of lncRNA XIST may also suppress cell migration and invasion in vitro. The present study suggested that lncRNA XIST acted as an oncogene in osteosarcoma, which may make it a novel therapeutic target for the treatment of osteosarcoma.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2017]版：

Q4 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 2.5 最新[2023版] 2.4 最新五年平均 1.664 出版当年[2017版] 1.654 出版当年五年平均 1.39 出版前一年[2016版] 1.871 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China

通讯作者：

通讯机构： [*1]Department of Orthopedics, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng, Beijing 100053, P.R. China

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