Occurrence of composite cardiac endpoints with change in resting heart rate among Chinese patients with coronary artery disease: Chinese cohort from the real-world BISO-CAD study
机构：[1]Department of Cardiology, China PLA General Hospital, Beijing, China[2]Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China[3]Affiliated Hospital of Guangdong Medical College, China[4]Sir Run Run Shaw Hospital Affiliated with School of Medicine, Zhejiang University, China[5]West China Hospital, China[6]The Second Xiangya Hospital of Central South University, China[7]Shanghai First People’s Hospital, China[8]Merck Serono China R&D, Beijing, China[9]Merck Serono Co. Ltd., Beijing, China[10]First Affiliated Hospital of Dalian Medical University, China[11]Affiliated Hospital of North Sichuan Medical College, China[12]Fu Xing Hospital, Capital Medical University, China[13]Zhongnan Hospital of Wuhan University, China[14]Xuanwu Hospital Capital Medical University, China首都医科大学宣武医院[15]The First Affiliated Hospital of the Fourth Military Medical University, China[16]Chinese Armed Police Force General Hospital, China[17]PLA, the Military General Hospital of Beijing, China[18]The Second Affiliated Hospital of the Fourth Military Medical University, China[19]The First People’s Hospital of Hangzhou, China[20]The People’s Hospital of Zhongshan City, China[21]Beijing Anzhen Hospital Capital Medical University, China[22]Xiangya Hospital of Central South University, China
Objective: We evaluated change in resting heart rate (RHR) and its impact on prognosis in Chinese coronary artery disease (CAD) patients treated with bisoprolol, and also assessed drug safety and tolerability. Methods: This phase IV, single arm observational study was a sub-study of the BISO-CAD study conducted across 20 hospitals in China between October 2011 and July 2015 with follow-up at 6, 12 and 18 months after baseline. The primary endpoint was occurrence of composite cardiac events. Results: A total of 663 CAD patients (baseline RHR 75.47 +/- 6.62 bpm) were enrolled in the intent-to-treat (ITT) set, and 513 patients were included in the efficacy analysis (EA) set. In the ITT set, the risk and the number of composite cardiac events in patients with mean RHR 69-74 bpm were significantly higher than in the <65 bpm group (ITT: estimate 1.03 +/- 0.47, p = .029). The incidence of the composite cardiac endpoint was not affected by continuous mean RHR (p = .5070). RHR significantly decreased from baseline to 18 months, most obviously in the first 6 months (p < .0001). Ejection fraction and fractional shortening significantly improved in both the ITT and EA sets. An average RHR of 69-74 bpm had a significant effect on admission to hospital for acute coronary syndrome in the ITT (estimate 1.10, HR 3.004, p = .0196) and EA (estimate 1.26, HR 3.526, p = .0132) groups. Seven (1.1%) patients reported drug related adverse events. Conclusion: Reduction in RHR with bisoprolol lowered the incidence of composite cardiac events along with an acceptable safety and tolerability profile.
基金：
Merck Serono Co. Ltd, an affiliate of Merck KGaA, Darmstadt, Germany
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区医学：内科3 区医学：研究与实验
最新[2023]版：
大类|4 区医学
小类|3 区医学：内科4 区医学：研究与实验
JCR分区：
出版当年[2016]版：
Q1MEDICINE, GENERAL & INTERNALQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, GENERAL & INTERNALQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Cardiology, China PLA General Hospital, Beijing, China
通讯作者：
通讯机构：[1]Department of Cardiology, China PLA General Hospital, Beijing, China
推荐引用方式(GB/T 7714)：
Chen Yundai,Yang Xinchun,Huang Shi'an,et al.Occurrence of composite cardiac endpoints with change in resting heart rate among Chinese patients with coronary artery disease: Chinese cohort from the real-world BISO-CAD study[J].CURRENT MEDICAL RESEARCH AND OPINION.2018,34(11):1921-1926.doi:10.1080/03007995.2018.1454895.
APA：
Chen, Yundai,Yang, Xinchun,Huang, Shi'an,Fu, Guosheng,Chen, Xiaoping...&Yang, Tianlun.(2018).Occurrence of composite cardiac endpoints with change in resting heart rate among Chinese patients with coronary artery disease: Chinese cohort from the real-world BISO-CAD study.CURRENT MEDICAL RESEARCH AND OPINION,34,(11)
MLA：
Chen, Yundai,et al."Occurrence of composite cardiac endpoints with change in resting heart rate among Chinese patients with coronary artery disease: Chinese cohort from the real-world BISO-CAD study".CURRENT MEDICAL RESEARCH AND OPINION 34..11(2018):1921-1926
